sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3q2j | CKI | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3q2j | CKI | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 1.000 | |
| 3tm0 | ANP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.584 | |
| 2bkk | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.558 | |
| 2b0q | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.501 | |
| 1j7l | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.493 | |
| 1l8t | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.469 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.469 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.467 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.464 | |
| 4bgb | ADP | Predicted molecular chaperone distantly related to HSP70-fold metalloproteases | / | 0.464 | |
| 1xh7 | R96 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.463 | |
| 3afh | GSU | Glutamate--tRNA ligase 2 | / | 0.457 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.456 | |
| 1ftl | DNQ | Glutamate receptor 2 | / | 0.455 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.453 | |
| 3h03 | UBP | Glutamate receptor 2 | / | 0.452 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.451 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.450 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.449 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.447 | |
| 2a4x | BLM | Mitomycin-binding protein | / | 0.446 | |
| 2acw | UPG | Glycosyltransferase | / | 0.446 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.446 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.446 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2j07 | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.444 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 1i9c | 5AD | Glutamate mutase epsilon subunit | / | 0.443 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.443 | |
| 4phl | PIL | Phosphodiesterase | / | 0.443 | |
| 2rd6 | 78P | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 3cnp | SP7 | Polyamine oxidase FMS1 | / | 0.442 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2j08 | IRF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.441 | |
| 2xvv | 9DN | Serum albumin | / | 0.441 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4iae | 1DX | Alr2278 protein | / | 0.441 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.440 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.440 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.440 | |
| 3gue | UPG | UTP-glucose-1-phosphate uridylyltransferase 2, putative | / | 0.440 |