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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3op5REBSerine/threonine-protein kinase VRK12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3op5REBSerine/threonine-protein kinase VRK12.7.11.11.000
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.514
4qo9627Serine/threonine-protein kinase 242.7.11.10.513
2henADPEphrin type-B receptor 22.7.10.10.478
2c6eHPMAurora kinase A2.7.11.10.477
3a7hATPSerine/threonine-protein kinase 242.7.11.10.477
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.474
2j0lANPFocal adhesion kinase 12.7.10.20.472
2qo7ANPEphrin type-A receptor 32.7.10.10.472
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.472
4k8aK8AFocal adhesion kinase 12.7.10.20.470
2qoqANPEphrin type-A receptor 32.7.10.10.468
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.466
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.466
4ansVGHALK tyrosine kinase receptor2.7.10.10.466
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.465
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.465
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.464
2j0m4STFocal adhesion kinase 12.7.10.20.464
3bqr4RBDeath-associated protein kinase 3/0.464
4gk4L90Ephrin type-A receptor 32.7.10.10.463
3my5RFZCyclin-dependent kinase 22.7.11.220.462
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.462
2yfxVGHALK tyrosine kinase receptor2.7.10.10.461
3c4xATPRhodopsin kinase/0.461
4qmlANPSerine/threonine-protein kinase 242.7.11.10.461
4jia1K3Tyrosine-protein kinase JAK2/0.460
2qocANPEphrin type-A receptor 32.7.10.10.458
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.458
3w2o03PEpidermal growth factor receptor2.7.10.10.458
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.457
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.457
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.457
2xvdAS6Ephrin type-B receptor 42.7.10.10.456
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.456
3q9xEMOCasein kinase II subunit alpha2.7.11.10.456
4b99R4LMitogen-activated protein kinase 72.7.11.240.456
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.456
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.456
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.455
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.455
4btjATPTau-tubulin kinase 12.7.11.10.455
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
1pjkANPCasein kinase II subunit alpha2.7.11.10.454
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4c4f7CEDual specificity protein kinase TTK2.7.12.10.453
4grb0XGCasein kinase II subunit alpha2.7.11.10.452
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.450
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.450
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
2ijmADPFocal adhesion kinase 12.7.10.20.449
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.449
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.449
3begANPSRSF protein kinase 12.7.11.10.448
4gu94GUFocal adhesion kinase 12.7.10.20.448
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.447
3hx4ANPCalmodulin-domain protein kinase 1/0.446
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.446
2c475IDCasein kinase I isoform gamma-2/0.445
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.444
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.444
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.444
4xhgADPUncharacterized protein/0.444
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
2etm7PYFocal adhesion kinase 12.7.10.20.443
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.443
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.443
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.442
2hw1ANPKetohexokinase/0.442
2zjwREFCasein kinase II subunit alpha2.7.11.10.442
4icyFADPgaE/0.442
3ztxZTXAurora kinase B-A2.7.11.10.441
5aacVGHALK tyrosine kinase receptor2.7.10.10.441
3lltANPProtein serine/threonine kinase-1/0.440
3pxkPXKFocal adhesion kinase 12.7.10.20.440
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.440