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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hl7I47Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3hl7I47Mitogen-activated protein kinase 14/1.000
4lopSB4Mitogen-activated protein kinase 14/0.648
3nww3NWMitogen-activated protein kinase 14/0.621
4loqSB4Mitogen-activated protein kinase 14/0.609
3fln3FNMitogen-activated protein kinase 14/0.598
3fklFKLMitogen-activated protein kinase 14/0.583
4aa4QC0Mitogen-activated protein kinase 14/0.582
4aacAAVMitogen-activated protein kinase 14/0.577
3hllI45Mitogen-activated protein kinase 14/0.576
3flyFLYMitogen-activated protein kinase 14/0.575
4aa5NQBMitogen-activated protein kinase 14/0.568
3fmh533Mitogen-activated protein kinase 14/0.564
4looSB4Mitogen-activated protein kinase 14/0.564
3fmkFMKMitogen-activated protein kinase 14/0.563
2balPQAMitogen-activated protein kinase 14/0.560
3iphG11Mitogen-activated protein kinase 14/0.558
4kiq1RAMitogen-activated protein kinase 14/0.558
3dt1P40Mitogen-activated protein kinase 14/0.553
3fi4FI4Mitogen-activated protein kinase 14/0.545
3flzFLZMitogen-activated protein kinase 14/0.543
4kip1R9Mitogen-activated protein kinase 14/0.537
3fskRO6Mitogen-activated protein kinase 14/0.536
3mvl38PMitogen-activated protein kinase 14/0.536
3roc29AMitogen-activated protein kinase 14/0.534
3mpaSB2Mitogen-activated protein kinase 14/0.532
4eh70OOMitogen-activated protein kinase 14/0.529
3s4qNK0Mitogen-activated protein kinase 14/0.527
1ywrLI9Mitogen-activated protein kinase 14/0.526
3hvcGG5Mitogen-activated protein kinase 14/0.525
4kin1M8Mitogen-activated protein kinase 14/0.523
1ouk084Mitogen-activated protein kinase 14/0.521
2ghlLIBMitogen-activated protein kinase 14/0.514
3flwFLWMitogen-activated protein kinase 14/0.510
4ewqMWLMitogen-activated protein kinase 14/0.510
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.510
1yw2PGJMitogen-activated protein kinase 14/0.509
3mpt1GKMitogen-activated protein kinase 14/0.508
3kf7L9GMitogen-activated protein kinase 14/0.503
4eh60ONMitogen-activated protein kinase 14/0.503
3ocgOCGMitogen-activated protein kinase 14/0.502
1zyjBI5Mitogen-activated protein kinase 14/0.501
3uyt0CKCasein kinase I isoform delta2.7.11.10.500
2rg5279Mitogen-activated protein kinase 14/0.498
2qd9LGFMitogen-activated protein kinase 14/0.495
3u8w09JMitogen-activated protein kinase 14/0.495
1eh4IC1Casein kinase I homolog 12.7.11.10.481
3gc9B45Mitogen-activated protein kinase 112.7.11.240.481
1zz2B11Mitogen-activated protein kinase 14/0.478
4fod0UVALK tyrosine kinase receptor2.7.10.10.478
3gubGUBDeath-associated protein kinase 12.7.11.10.477
4kb81QNCasein kinase I isoform delta2.7.11.10.477
3fl4FL4Mitogen-activated protein kinase 14/0.476
4kbk1QGCasein kinase I isoform delta2.7.11.10.474
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.473
4yuqKS1Calmodulin-like domain protein kinase/0.473
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.471
4hnf16WCasein kinase I isoform delta2.7.11.10.471
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.471
2rg6287Mitogen-activated protein kinase 14/0.470
3flsFLSMitogen-activated protein kinase 14/0.469
3o8tBMUMitogen-activated protein kinase 14/0.469
1rw8580TGF-beta receptor type-12.7.11.300.468
4nk92K5Fibroblast growth factor receptor 1/0.468
1bl6SB6Mitogen-activated protein kinase 14/0.467
4anqVGHALK tyrosine kinase receptor2.7.10.10.466
4qmzB49Serine/threonine-protein kinase 242.7.11.10.466
3hx4ANPCalmodulin-domain protein kinase 1/0.464
3zsh469Mitogen-activated protein kinase 14/0.464
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.464
3bv3P39Mitogen-activated protein kinase 14/0.463
3uzp0CKCasein kinase I isoform delta2.7.11.10.463
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.462
2j0m4STFocal adhesion kinase 12.7.10.20.461
1pkdUCNCyclin-dependent kinase 22.7.11.220.460
4i22IREEpidermal growth factor receptor2.7.10.10.460
4kb81QOCasein kinase I isoform delta2.7.11.10.460
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.459
3ttjJBIMitogen-activated protein kinase 102.7.11.240.459
4kbc1QJCasein kinase I isoform delta2.7.11.10.459
5e8wSTUTGF-beta receptor type-12.7.11.300.459
3fkoFKOMitogen-activated protein kinase 14/0.458
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.457
3iqfE4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.457
3p6oETGCamphor 5-monooxygenase1.14.15.10.457
4g170VNCasein kinase I isoform gamma-32.7.11.10.456
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.455
4fob0USALK tyrosine kinase receptor2.7.10.10.455
4nka2K7Fibroblast growth factor receptor 1/0.455
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.454
3atzFMNProstaglandin F2a synthase/0.454
4nks2M2Fibroblast growth factor receptor 1/0.454
2gtmLIDMitogen-activated protein kinase 14/0.453
2j5xGSPADP-ribosylation factor 6/0.453
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
3fmmXI2Mitogen-activated protein kinase 14/0.453
3l8xN4DMitogen-activated protein kinase 14/0.453
3ttiKBIMitogen-activated protein kinase 102.7.11.240.453
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.453
4kba1QMCasein kinase I isoform delta2.7.11.10.453
4riyADPEpidermal growth factor receptor2.7.10.10.453
1gih1PUCyclin-dependent kinase 22.7.11.220.452
2bqvA1AProtease/0.452
3gfeP37Mitogen-activated protein kinase 14/0.452
3uibSB2Putative mitogen-activated protein kinase/0.452
4cd2FOLDihydrofolate reductase1.5.1.30.452
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.452
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.452
1pmn984Mitogen-activated protein kinase 102.7.11.240.451
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.451
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.451
4eym0RXMitogen-activated protein kinase 132.7.11.240.451
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.451
4tuvCPZCytochrome P450 1191.140.451
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.450
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.450
3fknFKNMitogen-activated protein kinase 14/0.450
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.450
2x7gPVBSRSF protein kinase 22.7.11.10.449
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.449
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.449
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.449
1jpaANPEphrin type-B receptor 22.7.10.10.448
2zb0GK3Mitogen-activated protein kinase 14/0.448
3gw9VNILanosterol 14-alpha-demethylase/0.448
3mvm39PMitogen-activated protein kinase 14/0.448
3zsgT75Mitogen-activated protein kinase 14/0.448
4c62XWWTyrosine-protein kinase JAK2/0.448
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.448
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.448
1jolFFODihydrofolate reductase1.5.1.30.447
2excJNKMitogen-activated protein kinase 102.7.11.240.447
2qo9ANPEphrin type-A receptor 32.7.10.10.447
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.447
3da24MDCarbonic anhydrase 134.2.1.10.446
3hwrNDP2-dehydropantoate 2-reductase/0.446
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.446
4ic7ANPMitogen-activated protein kinase 72.7.11.240.446
4ih8B43Calmodulin-domain protein kinase 1/0.446
1c1dNAIPhenylalanine dehydrogenase/0.445
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.445
1w2xRCPAcetyl-CoA carboxylase/0.445
2c5nCK8Cyclin-dependent kinase 22.7.11.220.445
2znq401Peroxisome proliferator-activated receptor delta/0.445
1m7qDQOMitogen-activated protein kinase 14/0.444
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.444
3fmn530Mitogen-activated protein kinase 14/0.444
3iqeF42F420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.444
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.444
4b4vL34Bifunctional protein FolD/0.444
4jx1CAMCamphor 5-monooxygenase1.14.15.10.444
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.444
5auuLU2Death-associated protein kinase 12.7.11.10.444
1ove358Mitogen-activated protein kinase 14/0.443
2jedLG8Protein kinase C theta type2.7.11.130.443
4ansVGHALK tyrosine kinase receptor2.7.10.10.443
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.443
4c02TAKActivin receptor type-12.7.11.300.443
4kl9NDPDihydrofolate reductase1.5.1.30.443
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
1di8DTQCyclin-dependent kinase 22.7.11.220.442
5aacVGHALK tyrosine kinase receptor2.7.10.10.442
1bygSTUTyrosine-protein kinase CSK/0.441
2iw94SPCyclin-dependent kinase 22.7.11.220.441
2q61SF1Peroxisome proliferator-activated receptor gamma/0.441
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.441
2xa4AZ5Tyrosine-protein kinase JAK2/0.441
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.441
3i7eDJRGag-Pol polyprotein/0.441
3le62BZCyclin-dependent kinase 22.7.11.220.441
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.441
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.441
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.441
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.441
1rfuADPPyridoxal kinase2.7.1.350.440
1tduDURThymidylate synthase/0.440
2q7vFADThioredoxin reductase/0.440
3iqeH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.440
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.440
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.440