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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3esyFMNFlavodoxin

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3esyFMNFlavodoxin/1.000
3eszFMNFlavodoxin/0.575
1ahnFMNFlavodoxin 1/0.534
3f6rFMNFlavodoxin/0.523
4y7cFMNNADPH--cytochrome P450 reductase/0.518
3ojxFMNNADPH--cytochrome P450 reductase/0.512
1cznFMNFlavodoxin/0.500
2e0nSAHPrecorrin-2 C20-methyltransferase/0.485
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.476
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.476
1j9gFMNFlavodoxin/0.475
5xr8FMNCannabinoid receptor 1/0.475
1f4eTPRThymidylate synthase/0.472
3n3aFMNProtein NrdI/0.471
3ensENSCoagulation factor X3.4.21.60.469
3fpkFADFerredoxin-NADP reductase/0.469
4ea2RWZDehydrosqualene synthase/0.468
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.464
1fx1FMNFlavodoxin/0.463
1ofvFMNFlavodoxin/0.462
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.461
1azlFMNFlavodoxin/0.460
1akwFMNFlavodoxin/0.459
1xyyFMNFlavodoxin/0.459
4m0f1YKAcetylcholinesterase3.1.1.70.459
1j9zFMNNADPH--cytochrome P450 reductase/0.458
2whqHI6Acetylcholinesterase3.1.1.70.458
3af1GDPPantothenate kinase2.7.1.330.458
4brdANPEctonucleoside triphosphate diphosphohydrolase I/0.458
1j8qFMNFlavodoxin/0.457
2mokFMNFlavodoxin 1/0.457
1bu5RBFFlavodoxin/0.455
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.455
2v5vFMNFlavodoxin/0.454
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3zv7NHGAcetylcholinesterase3.1.1.70.454
2x86ADPADP-L-glycero-D-manno-heptose-6-epimerase/0.453
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.451
2c29NAPDihydroflavonol 4-reductase/0.451
4oxxFMNCindoxin/0.451
2vqbNAPPutative flavin-containing monooxygenase/0.450
2hpvFMNFMN-dependent NADH-azoreductase1.70.448
3m2vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.448
1zgbA1EAcetylcholinesterase3.1.1.70.447
3kapFMNFlavodoxin/0.447
3mauPLRPutative sphingosine-1-phosphate lyase/0.447
1bduDURThymidylate synthase/0.446
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.446
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.445
2c20NADUDP-glucose 4-epimerase/0.445
2cekN8TAcetylcholinesterase3.1.1.70.445
2g1s4IGRenin3.4.23.150.445
3hl0NADMaleylacetate reductase/0.445
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.445
1fmlRTLRetinol dehydratase/0.444
1ut6A8NAcetylcholinesterase3.1.1.70.443
1x2eATXProline iminopeptidase3.4.11.50.442
2po3T4K4-dehydrase/0.442
3cluFADElectron transfer flavoprotein subunit alpha/0.442
1gpnHUBAcetylcholinesterase3.1.1.70.441
3klbFMNUncharacterized protein/0.441
1fxuGU7Purine nucleoside phosphorylase2.4.2.10.440
3ojwFMNNADPH--cytochrome P450 reductase/0.440
3ojxFADNADPH--cytochrome P450 reductase/0.440
4lxk1YTBeta-secretase 13.4.23.460.440