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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3e30ED4Protein farnesyltransferase subunit beta2.5.1.58

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3e30ED4Protein farnesyltransferase subunit beta2.5.1.581.000
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.642
1s63778Protein farnesyltransferase subunit beta2.5.1.580.628
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.623
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.622
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.618
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.614
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.607
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.605
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.600
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.600
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.598
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.595
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.585
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.573
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.569
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.556
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.553
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.550
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.517
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.507
3q7fED2Uncharacterized protein/0.506
4gto7TOProtein farnesyltransferase subunit beta2.5.1.580.506
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.496
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.484
3sfy3FYUncharacterized protein/0.481
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.479
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.462
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.462
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.458
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.449