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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.301.000
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.300.691
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.665
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.615
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.576
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.569
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.536
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.526
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.524
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.515
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.509
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.509
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.507
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.506
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.503
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.501
3l3lL3LPoly [ADP-ribose] polymerase 12.4.2.300.499
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.478
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.466
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.456
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.300.454
4pnmNU1Tankyrase-22.4.2.300.451
5ds309LPoly [ADP-ribose] polymerase 12.4.2.300.449
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.440