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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.11.000
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.503
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.501
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.497
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.493
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.491
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.483
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.481
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.481
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.479
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.479
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.474
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.469
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.469
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.467
3nynSGVG protein-coupled receptor kinase 62.7.11.160.466
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.465
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.465
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.462
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.462
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.462
2ckeIQUDeath-associated protein kinase 2/0.461
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.461
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.461
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.460
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.460
1zys199Serine/threonine-protein kinase Chk12.7.11.10.459
5av2KMPDeath-associated protein kinase 12.7.11.10.459
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.458
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.456
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.456
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.456
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.455
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.455
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.454
4y95746Tyrosine-protein kinase/0.454
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.454
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.452
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.452
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.451
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.451
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.450
4dymIYZActivin receptor type-12.7.11.300.450
4c02TAKActivin receptor type-12.7.11.300.449
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.448
4dtaADNAPH(2'')-Id/0.448
4y93746Tyrosine-protein kinase/0.448
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.447
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.446
3w2sW2REpidermal growth factor receptor2.7.10.10.446
3bqr4RBDeath-associated protein kinase 3/0.444
3mtfA3FActivin receptor type-12.7.11.300.444
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.444
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.443
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.443
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.442
2hog710Serine/threonine-protein kinase Chk12.7.11.10.441
2pvmP29Casein kinase II subunit alpha2.7.11.10.441
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.441
4o0wADNAurora kinase A2.7.11.10.441