Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdlTOLAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2pdlTOLAldose reductase1.1.1.211.000
2fzbTOLAldose reductase1.1.1.210.637
1ah3TOLAldose reductase1.1.1.210.629
2fzdTOLAldose reductase1.1.1.210.593
2pdh47DAldose reductase1.1.1.210.583
2pdfZSTAldose reductase1.1.1.210.569
1zuaTOLAldo-keto reductase family 1 member B101.1.10.530
3ghrLDTAldose reductase1.1.1.210.530
2fz8ZSTAldose reductase1.1.1.210.529
2i16LDTAldose reductase1.1.1.210.518
4wevSUZAldo-keto reductase family 1 member B101.1.10.509
3ghsLDTAldose reductase1.1.1.210.503
2duzZSTAldose reductase1.1.1.210.491
2dv0ZSTAldose reductase1.1.1.210.486
3ghtLDTAldose reductase1.1.1.210.486
2hv5ZSTAldose reductase1.1.1.210.483
3m64393Aldose reductase1.1.1.210.479
1ry0PG2Aldo-keto reductase family 1 member C3/0.475
1z8962PAldose reductase1.1.1.210.474
2fz9ZSTAldose reductase1.1.1.210.474
2ikj393Aldose reductase1.1.1.210.473
4pnmNU1Tankyrase-22.4.2.300.472
1z3n3NAAldose reductase1.1.1.210.471
2i17LDTAldose reductase1.1.1.210.470
2hvoZSTAldose reductase1.1.1.210.469
2pzn393Aldose reductase1.1.1.210.467
1zq5E04Aldo-keto reductase family 1 member C3/0.466
5liu388Aldo-keto reductase family 1 member B101.1.10.466
3ld5LDTAldose reductase1.1.1.210.465
2iki388Aldose reductase1.1.1.210.464
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.464
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
3ghuLDTAldose reductase1.1.1.210.461
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.460
3r43ID8Aldo-keto reductase family 1 member C3/0.460
4fam0SZAldo-keto reductase family 1 member C3/0.458
4gca2X9Aldose reductase1.1.1.210.458
3lenZSTAldose reductase1.1.1.210.456
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.454
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.452
2f3815MAldo-keto reductase family 1 member C3/0.451
2ikhLITAldose reductase1.1.1.210.451
2bjsACVIsopenicillin N synthase1.21.3.10.449
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.447
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.447
2vbpVB1Isopenicillin N synthase1.21.3.10.446
3g5eQ74Aldose reductase1.1.1.210.446
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2pdp393Aldose reductase1.1.1.210.445
2pdwFIDAldose reductase1.1.1.210.445
2vrjNCWBeta-glucosidase A3.2.1.210.444
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.444
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.442
4kxjP34Nucleoprotein/0.442
2j7cIDEBeta-glucosidase A3.2.1.210.441
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.441
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.441
2pdu393Aldose reductase1.1.1.210.440
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440