scPDB - Distribution of Cavity Similarity values of 2pdh entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2pdh	47D	Aldose reductase	1.1.1.21

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
2pdh	47D	Aldose reductase	1.1.1.21	1.000
2pdf	ZST	Aldose reductase	1.1.1.21	0.649
2pdl	TOL	Aldose reductase	1.1.1.21	0.545
2fzd	TOL	Aldose reductase	1.1.1.21	0.532
1ah3	TOL	Aldose reductase	1.1.1.21	0.527
2hvo	ZST	Aldose reductase	1.1.1.21	0.520
2pdn	47D	Aldose reductase	1.1.1.21	0.519
2pdj	393	Aldose reductase	1.1.1.21	0.513
2dv0	ZST	Aldose reductase	1.1.1.21	0.507
2fz8	ZST	Aldose reductase	1.1.1.21	0.507
2fzb	TOL	Aldose reductase	1.1.1.21	0.507
2pdg	47D	Aldose reductase	1.1.1.21	0.507
4gca	2X9	Aldose reductase	1.1.1.21	0.502
2hv5	ZST	Aldose reductase	1.1.1.21	0.499
2hvn	ZST	Aldose reductase	1.1.1.21	0.496
2pdm	ZST	Aldose reductase	1.1.1.21	0.493
1zua	TOL	Aldo-keto reductase family 1 member B10	1.1.1	0.492
3mb9	ZST	Aldose reductase	1.1.1.21	0.492
3m0i	ZST	Aldose reductase	1.1.1.21	0.490
1t40	ID5	Aldose reductase	1.1.1.21	0.485
1z89	62P	Aldose reductase	1.1.1.21	0.485
2pdu	393	Aldose reductase	1.1.1.21	0.485
2fz9	ZST	Aldose reductase	1.1.1.21	0.482
2pzn	393	Aldose reductase	1.1.1.21	0.482
2ikj	393	Aldose reductase	1.1.1.21	0.481
2pdb	ZST	Aldose reductase	1.1.1.21	0.481
3t42	3T4	Aldose reductase	1.1.1.21	0.480
4wev	SUZ	Aldo-keto reductase family 1 member B10	1.1.1	0.478
2iki	388	Aldose reductase	1.1.1.21	0.477
3ght	LDT	Aldose reductase	1.1.1.21	0.476
3wd9	QPC	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.476
2pdx	ZST	Aldose reductase	1.1.1.21	0.475
1tbb	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.474
3m64	393	Aldose reductase	1.1.1.21	0.473
2i16	LDT	Aldose reductase	1.1.1.21	0.472
1z3n	3NA	Aldose reductase	1.1.1.21	0.471
1t41	ID5	Aldose reductase	1.1.1.21	0.470
3lbo	LDT	Aldose reductase	1.1.1.21	0.470
2dux	ZST	Aldose reductase	1.1.1.21	0.469
3ghs	LDT	Aldose reductase	1.1.1.21	0.469
3ghu	LDT	Aldose reductase	1.1.1.21	0.467
3mc5	393	Aldose reductase	1.1.1.21	0.467
3ghr	LDT	Aldose reductase	1.1.1.21	0.466
3m4h	388	Aldose reductase	1.1.1.21	0.465
2i17	LDT	Aldose reductase	1.1.1.21	0.464
1pwl	BFI	Aldose reductase	1.1.1.21	0.463
3ld5	LDT	Aldose reductase	1.1.1.21	0.463
3fvu	IAC	Kynurenine--oxoglutarate transaminase 1	2.6.1.7	0.462
3v94	WYQ	Phosphodiesterase	/	0.462
1zkl	IBM	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	3.1.4.53	0.460
3w5e	NVW	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.460
2pd5	ZST	Aldose reductase	1.1.1.21	0.459
3g5e	Q74	Aldose reductase	1.1.1.21	0.459
3lql	LDT	Aldose reductase	1.1.1.21	0.457
1us0	LDT	Aldose reductase	1.1.1.21	0.455
1xoq	ROF	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.455
2duz	ZST	Aldose reductase	1.1.1.21	0.453
2qxw	LDT	Aldose reductase	1.1.1.21	0.453
3k4s	0MO	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.453
1xor	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.450
2ouu	35G	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.450
3len	ZST	Aldose reductase	1.1.1.21	0.450
2iqd	LPA	Aldose reductase	1.1.1.21	0.448
4hcy	0YN	Transketolase	/	0.447
4jvm	XDI	Estrogen sulfotransferase	2.8.2.4	0.446
4jvn	YUG	Estrogen sulfotransferase	2.8.2.4	0.445
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.443
3g4i	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.442
3lz5	LDT	Aldose reductase	1.1.1.21	0.442
4hhz	15S	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.442
1w22	NHB	Histone deacetylase 8	3.5.1.98	0.441
1q9m	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.440
1xom	CIO	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.440