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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2g8dUMPThymidylate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2g8dUMPThymidylate synthase/1.000
2g8aUMPThymidylate synthase/0.748
2g89UMPThymidylate synthase/0.700
1jmhUMPThymidylate synthase/0.651
2g86UMPThymidylate synthase/0.637
1thyUMPThymidylate synthase/0.609
1tsvUMPThymidylate synthase/0.608
2tddTHFThymidylate synthase/0.604
1njbUMPThymidylate synthase/0.602
1njcDCMThymidylate synthase/0.596
1bp6UMPThymidylate synthase/0.594
1njeDCMThymidylate synthase/0.592
1bp0UMPThymidylate synthase/0.578
1njaDCMThymidylate synthase/0.578
1tdcUMPThymidylate synthase/0.567
1jmfUMPThymidylate synthase/0.563
1bidUMPThymidylate synthase/0.555
1jmgUMPThymidylate synthase/0.548
1vzaUMPThymidylate synthase/0.541
2vf0F89Thymidylate synthase/0.538
2tdmUMPThymidylate synthase/0.537
1njdUMPThymidylate synthase/0.536
4einNOHThymidylate synthase2.1.1.450.522
1jmiUMPThymidylate synthase/0.521
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.519
1vzdCB3Thymidylate synthase/0.516
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.512
1bpjUMPThymidylate synthase/0.509
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.508
3qj7UMPThymidylate synthase ThyA/0.499
2vetUMPThymidylate synthase/0.494
4e5oUMPThymidylate synthase2.1.1.450.494
1tsxUMPThymidylate synthase/0.487
1tlcF89Thymidylate synthase/0.483
4h0uUMPThymidylate synthase/0.483
1bduDURThymidylate synthase/0.479
4dq1UMPThymidylate synthase/0.474
1f4eTPRThymidylate synthase/0.470
4irrUMPThymidylate synthase/0.467
1vzbUMPThymidylate synthase/0.465
4eb4UMPThymidylate synthase2.1.1.450.465
4fogC2FThymidylate synthase ThyA/0.463
1f28UMPThymidylate synthase2.1.1.450.461
4iskUMPThymidylate synthase/0.461
2ftoTMPThymidylate synthase/0.457
1j3jUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.453
3bhrTHGThymidylate synthase/0.451
1aobDDUThymidylate synthase/0.445
4ez8DHFThymidylate synthase2.1.1.450.445
4xsdUMPThymidylate synthase2.1.1.450.442
3hb8UMPThymidylate synthase2.1.1.450.440