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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fzdTOLAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2fzdTOLAldose reductase1.1.1.211.000
1ah3TOLAldose reductase1.1.1.210.611
2pdlTOLAldose reductase1.1.1.210.592
2pdh47DAldose reductase1.1.1.210.562
2pdxZSTAldose reductase1.1.1.210.553
1zuaTOLAldo-keto reductase family 1 member B101.1.10.551
2fz9ZSTAldose reductase1.1.1.210.549
2pdfZSTAldose reductase1.1.1.210.540
4wevSUZAldo-keto reductase family 1 member B101.1.10.521
2fzbTOLAldose reductase1.1.1.210.518
2dv0ZSTAldose reductase1.1.1.210.507
3m4h388Aldose reductase1.1.1.210.502
4gca2X9Aldose reductase1.1.1.210.498
5liu388Aldo-keto reductase family 1 member B101.1.10.496
3lqlLDTAldose reductase1.1.1.210.495
1z3n3NAAldose reductase1.1.1.210.494
2hv5ZSTAldose reductase1.1.1.210.491
3lboLDTAldose reductase1.1.1.210.488
3g5eQ74Aldose reductase1.1.1.210.487
3m64393Aldose reductase1.1.1.210.479
1z8962PAldose reductase1.1.1.210.476
3lz5LDTAldose reductase1.1.1.210.475
2fz8ZSTAldose reductase1.1.1.210.472
4yu153NAldose reductase1.1.1.210.472
3mb9ZSTAldose reductase1.1.1.210.470
1ry0PG2Aldo-keto reductase family 1 member C3/0.469
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
3ghuLDTAldose reductase1.1.1.210.467
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.465
3lenZSTAldose reductase1.1.1.210.465
1w6jR71Lanosterol synthase5.4.99.70.464
2pdu393Aldose reductase1.1.1.210.464
4y1bNAPAntE/0.464
3v35NTIAldose reductase1.1.1.210.463
2hvoZSTAldose reductase1.1.1.210.462
2inzOHPAldose reductase1.1.1.210.462
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
2pd9FIDAldose reductase1.1.1.210.461
2iki388Aldose reductase1.1.1.210.460
1zq5E04Aldo-keto reductase family 1 member C3/0.458
2ikj393Aldose reductase1.1.1.210.458
2qxwLDTAldose reductase1.1.1.210.458
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.456
2iqdLPAAldose reductase1.1.1.210.455
2pdj393Aldose reductase1.1.1.210.455
3mc5393Aldose reductase1.1.1.210.455
2pdp393Aldose reductase1.1.1.210.454
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
4pnmNU1Tankyrase-22.4.2.300.453
1us0LDTAldose reductase1.1.1.210.452
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
1ekoI84Aldose reductase1.1.1.210.451
1t41ID5Aldose reductase1.1.1.210.451
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.451
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.450
2pdwFIDAldose reductase1.1.1.210.450
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.450
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.449
2duxZSTAldose reductase1.1.1.210.447
2wo7ASVIsopenicillin N synthase1.21.3.10.447
2f2kTGGAldose reductase1.1.1.210.446
3zkyWT4Isopenicillin N synthase1.21.3.10.446
1zgcA2EAcetylcholinesterase3.1.1.70.445
2i16LDTAldose reductase1.1.1.210.445
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2xegCI9Glutamate carboxypeptidase 23.4.17.210.444
4fam0SZAldo-keto reductase family 1 member C3/0.444
4l1xNAPAldo-keto reductase family 1 member C2/0.444
1ry8RUTAldo-keto reductase family 1 member C3/0.443
1bk0ACVIsopenicillin N synthase1.21.3.10.442
2vcmM11Isopenicillin N synthase1.21.3.10.442
3ghrLDTAldose reductase1.1.1.210.442
1n5vNOMActVA 6 protein/0.441
1t40ID5Aldose reductase1.1.1.210.441
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
2xviFADPutative flavin-containing monooxygenase/0.440
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.440