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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ble5GPGMP reductase 1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ble5GPGMP reductase 1/1.000
2bwg5GPGMP reductase 1/0.640
4qq3XMPInosine-5'-monophosphate dehydrogenase/0.504
4dpwAGSMevalonate diphosphate decarboxylase/0.485
1u4oNDDL-lactate dehydrogenase1.1.1.270.470
2gs7ANPEpidermal growth factor receptor2.7.10.10.464
1me7RVPInosine-5'-monophosphate dehydrogenase/0.463
2xaaNADSecondary alcohol dehydrogenase/0.462
1me7MOAInosine-5'-monophosphate dehydrogenase/0.461
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.461
2zgzGNPPlasmid segregation protein ParM/0.457
1lbcCYZGlutamate receptor 2/0.456
2yyuC5POrotidine 5'-phosphate decarboxylase/0.456
3ea4FABAcetolactate synthase, chloroplastic2.2.1.60.456
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.456
2zgyGDPPlasmid segregation protein ParM/0.455
1k6cMK1Gag-Pol polyprotein3.4.23.160.454
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.453
4fn4NADShort chain dehydrogenase/0.452
4yaf2AMNADPH--cytochrome P450 reductase/0.452
1gcoNADGlucose 1-dehydrogenase1.1.1.470.451
4gh5NADShort-chain dehydrogenase/reductase SDR/0.451
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.450
1pdhFASp-hydroxybenzoate hydroxylase/0.450
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.449
2hjrAPRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase/0.448
3p8z36AGenome polyprotein2.1.1.560.448
3ukuC69Actin-related protein 3/0.448
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.447
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.447
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.446
4dieC5PCytidylate kinase/0.446
1mwmADPPlasmid segregation protein ParM/0.445
1z7yAA5Cysteine synthase 12.5.1.470.445
2cduFADNADH oxidase/0.445
2znq401Peroxisome proliferator-activated receptor delta/0.445
1gpdNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.444
1mg5NAIAlcohol dehydrogenase1.1.1.10.444
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.444
3nwxKVSGag-Pol polyprotein3.4.23.160.444
3s55NADPutative short-chain dehydrogenase/reductase/0.444
1j21ATPArgininosuccinate synthase/0.443
1kf6FADFumarate reductase flavoprotein subunit1.3.5.40.443
1xq6NAPUncharacterized protein At5g02240/0.443
2qnqQN3Gag-Pol polyprotein3.4.23.160.443
3anmNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.443
3bgbLJGGag-Pol polyprotein3.4.23.160.443
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.443
1ybaNADD-3-phosphoglycerate dehydrogenase1.1.1.950.442
2om9AJAPeroxisome proliferator-activated receptor gamma/0.442
2p5uNADUDP-glucose 4-epimerase/0.442
3w0gW07Vitamin D3 receptor/0.442
4ntdFADThioredoxin reductase/0.442
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.442
1civNAPMalate dehydrogenase [NADP], chloroplastic1.1.1.820.441
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.441
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.441
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.441
4qecNAPElxO/0.441
1bmdNADMalate dehydrogenase/0.440
2fznFADBifunctional protein PutA1.5.5.20.440
3fskRO6Mitogen-activated protein kinase 14/0.440