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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1vjy460TGF-beta receptor type-12.7.11.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1vjy460TGF-beta receptor type-12.7.11.301.000
3hmm855TGF-beta receptor type-12.7.11.300.704
3gxlQIGTGF-beta receptor type-12.7.11.300.629
2wotZZGTGF-beta receptor type-12.7.11.300.588
2wouZZFTGF-beta receptor type-12.7.11.300.558
1py5PY1TGF-beta receptor type-12.7.11.300.547
4c02TAKActivin receptor type-12.7.11.300.543
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.537
1rw8580TGF-beta receptor type-12.7.11.300.534
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.519
3mtfA3FActivin receptor type-12.7.11.300.514
4dymIYZActivin receptor type-12.7.11.300.514
5e8ySTUTGF-beta receptor type-22.7.11.300.505
1eh4IC1Casein kinase I homolog 12.7.11.10.502
1g5sI17Cyclin-dependent kinase 22.7.11.220.501
4fkv61KCyclin-dependent kinase 22.7.11.220.499
1bygSTUTyrosine-protein kinase CSK/0.498
1om1IQACasein kinase II subunit alpha2.7.11.10.497
2btsU32Cyclin-dependent kinase 22.7.11.220.495
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.493
3w33W19Epidermal growth factor receptor2.7.10.10.492
4dgnLU2Casein kinase II subunit alpha2.7.11.10.490
1u4dDBQActivated CDC42 kinase 1/0.489
1pxlCK4Cyclin-dependent kinase 22.7.11.220.488
4bgg844Activin receptor type-12.7.11.300.487
1oirHDYCyclin-dependent kinase 22.7.11.220.486
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.486
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.486
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.485
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.484
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.483
4fkpLS5Cyclin-dependent kinase 22.7.11.220.483
1oitHDTCyclin-dependent kinase 22.7.11.220.482
5cnoANPEpidermal growth factor receptor2.7.10.10.482
1aq1STUCyclin-dependent kinase 22.7.11.220.480
1di8DTQCyclin-dependent kinase 22.7.11.220.479
1xkkFMMEpidermal growth factor receptor2.7.10.10.479
5e92ANPTGF-beta receptor type-22.7.11.300.479
1y91CT9Cyclin-dependent kinase 22.7.11.220.478
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.478
4k33ACPFibroblast growth factor receptor 32.7.10.10.478
5cnnANPEpidermal growth factor receptor2.7.10.10.478
3sheI85MAP kinase-activated protein kinase 32.7.11.10.477
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.476
3lfnA27Cyclin-dependent kinase 22.7.11.220.476
1h1s4SPCyclin-dependent kinase 22.7.11.220.475
1m2pHNACasein kinase II subunit alpha2.7.11.10.473
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.473
3zh8C58Protein kinase C iota type2.7.11.130.473
3lfqA28Cyclin-dependent kinase 22.7.11.220.471
3w32W32Epidermal growth factor receptor2.7.10.10.471
4hge15VTyrosine-protein kinase JAK2/0.471
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.471
1gii1PUCyclin-dependent kinase 22.7.11.220.470
2pvhP19Casein kinase II subunit alpha2.7.11.10.469
4i22IREEpidermal growth factor receptor2.7.10.10.469
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.468
4dgmAGICasein kinase II subunit alpha2.7.11.10.468
4ek610KCyclin-dependent kinase 22.7.11.220.468
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.466
3uyt0CKCasein kinase I isoform delta2.7.11.10.466
4y95746Tyrosine-protein kinase/0.466
2xikJ60Serine/threonine-protein kinase 252.7.11.10.465
3qu0X40Cyclin-dependent kinase 22.7.11.220.465
2x1nX1NCyclin-dependent kinase 22.7.11.220.464
3rk708ZCyclin-dependent kinase 22.7.11.220.464
4iwd1JCHepatocyte growth factor receptor2.7.10.10.464
2w1hL0FCyclin-dependent kinase 22.7.11.220.462
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.462
1u54ACPActivated CDC42 kinase 1/0.461
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.461
3le62BZCyclin-dependent kinase 22.7.11.220.461
4eon1ROCyclin-dependent kinase 22.7.11.220.461
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.460
3be9P04Casein kinase II subunit alpha2.7.11.10.460
3rni21ZCyclin-dependent kinase 22.7.11.220.460
4qmpDKISerine/threonine-protein kinase 242.7.11.10.460
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.459
3rak03ZCyclin-dependent kinase 22.7.11.220.459
3rmf20ZCyclin-dependent kinase 22.7.11.220.459
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.459
2a0cCK9Cyclin-dependent kinase 22.7.11.220.458
2gjlFMNNitronate monooxygenase1.13.12.160.458
2iw84SPCyclin-dependent kinase 22.7.11.220.458
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.458
3oom507Activin receptor type-12.7.11.300.458
4fkg4CKCyclin-dependent kinase 22.7.11.220.458
2xa4AZ5Tyrosine-protein kinase JAK2/0.457
3iok1P6Tyrosine-protein kinase JAK2/0.457
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.457
4kbk1QGCasein kinase I isoform delta2.7.11.10.457
1w0xOLOCyclin-dependent kinase 22.7.11.220.456
3nynSGVG protein-coupled receptor kinase 62.7.11.160.456
3s1h56ZCyclin-dependent kinase 22.7.11.220.456
4anmWULCasein kinase II subunit alpha2.7.11.10.456
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.455
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.455
4qnaX11Serine/threonine-protein kinase 242.7.11.10.455
1ykr628Cyclin-dependent kinase 22.7.11.220.454
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.454
2pvnP63Casein kinase II subunit alpha2.7.11.10.454
4ek816KCyclin-dependent kinase 22.7.11.220.454
4fki09KCyclin-dependent kinase 22.7.11.220.454
1pxoCK7Cyclin-dependent kinase 22.7.11.220.453
4c61LMMTyrosine-protein kinase JAK2/0.453
4f081RSTyrosine-protein kinase JAK2/0.453
4fkt48KCyclin-dependent kinase 22.7.11.220.453
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.453
3rvg17PTyrosine-protein kinase JAK2/0.452
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.452
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.452
4f650S9Fibroblast growth factor receptor 1/0.452
1m2rMNYCasein kinase II subunit alpha2.7.11.10.450
2b52D42Cyclin-dependent kinase 22.7.11.220.450
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.450
2r3lSCWCyclin-dependent kinase 22.7.11.220.450
3ezvEZVCyclin-dependent kinase 22.7.11.220.450
4acm7YGCyclin-dependent kinase 22.7.11.220.450
4dgo0JWCasein kinase II subunit alpha2.7.11.10.450
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.450
4y93746Tyrosine-protein kinase/0.450
2gjnFMNNitronate monooxygenase1.13.12.160.449
2r3jSCJCyclin-dependent kinase 22.7.11.220.449
3eyhIZATyrosine-protein kinase JAK1/0.449
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.448
1gih1PUCyclin-dependent kinase 22.7.11.220.448
2w06FRVCyclin-dependent kinase 22.7.11.220.448
4jia1K3Tyrosine-protein kinase JAK2/0.448
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.448
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.447
3r8lZ30Cyclin-dependent kinase 22.7.11.220.447
4e4m0NHTyrosine-protein kinase JAK2/0.447
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.447
1ke6LS2Cyclin-dependent kinase 22.7.11.220.446
1pmn984Mitogen-activated protein kinase 102.7.11.240.446
2pvlP55Casein kinase II subunit alpha2.7.11.10.446
3gubGUBDeath-associated protein kinase 12.7.11.10.446
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.446
2xmyCDKCyclin-dependent kinase 22.7.11.220.445
3zmmF9JTyrosine-protein kinase JAK2/0.445
4eor4SPCyclin-dependent kinase 22.7.11.220.445
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.444
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.444
3ggfGVDSerine/threonine-protein kinase 26/0.444
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.444
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.444
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
2iw94SPCyclin-dependent kinase 22.7.11.220.443
2zoq5IDMitogen-activated protein kinase 32.7.11.240.443
3a60STURibosomal protein S6 kinase beta-12.7.11.10.443
3qzgX67Cyclin-dependent kinase 22.7.11.220.443
3r83Z14Cyclin-dependent kinase 22.7.11.220.443
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.443
5e8xSTUTGF-beta receptor type-12.7.11.300.443
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.442
3rk909ZCyclin-dependent kinase 22.7.11.220.442
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.442
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1ke7LS3Cyclin-dependent kinase 22.7.11.220.441
2vv9IM9Cyclin-dependent kinase 22.7.11.220.441
4btjADPTau-tubulin kinase 12.7.11.10.441
4qmlANPSerine/threonine-protein kinase 242.7.11.10.441
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.440
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.440
4grb0XGCasein kinase II subunit alpha2.7.11.10.440
4jq7KJQEpidermal growth factor receptor2.7.10.10.440