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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.261.000
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.585
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.561
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.522
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.520
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.519
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.514
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.507
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.488
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.486
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.486
1fvv107Cyclin-dependent kinase 22.7.11.220.478
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.478
4dgmAGICasein kinase II subunit alpha2.7.11.10.478
3eb0DRKUncharacterized protein/0.475
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.474
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.473
2pvhP19Casein kinase II subunit alpha2.7.11.10.473
4dgnLU2Casein kinase II subunit alpha2.7.11.10.473
2vu3LZECyclin-dependent kinase 22.7.11.220.472
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.471
3rak03ZCyclin-dependent kinase 22.7.11.220.464
3be9P04Casein kinase II subunit alpha2.7.11.10.462
3ezrEZRCyclin-dependent kinase 22.7.11.220.462
4fv6E57Mitogen-activated protein kinase 12.7.11.240.461
2fvdLIACyclin-dependent kinase 22.7.11.220.460
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.460
4bcmT7ZCyclin-dependent kinase 22.7.11.220.458
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.456
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.456
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.453
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.453
1w0xOLOCyclin-dependent kinase 22.7.11.220.452
2vv9IM9Cyclin-dependent kinase 22.7.11.220.450
4anmWULCasein kinase II subunit alpha2.7.11.10.448
2btrU73Cyclin-dependent kinase 22.7.11.220.446
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.445
4ez50RSCyclin-dependent kinase 62.7.11.220.444
5e8ySTUTGF-beta receptor type-22.7.11.300.443
3s1h56ZCyclin-dependent kinase 22.7.11.220.442
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.441
1gii1PUCyclin-dependent kinase 22.7.11.220.440
2pvmP29Casein kinase II subunit alpha2.7.11.10.440
2pvnP63Casein kinase II subunit alpha2.7.11.10.440
3zh8C58Protein kinase C iota type2.7.11.130.440