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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1l4lNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1l4lNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.211.000
1l4hNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.746
1l4kNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.683
1jhrP2PNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.658
1l4mNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.654
1l4fNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.616
1jhoRMBNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.609
1l4eRBZNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.603
1d0vRBZNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.581
1l5l7RPNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.575
1l4gNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.569
1l5k1RBNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.548
1jhaAAMNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.535
1l5oNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.519
1l5m7RANicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.495
4rcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.466
1phePIYCamphor 5-monooxygenase1.14.15.10.461
4du82P0Mevalonate diphosphate decarboxylase/0.460
1t2cNAIL-lactate dehydrogenase1.1.1.270.459
4aa4QC0Mitogen-activated protein kinase 14/0.459
3ijoB4DGlutamate receptor 2/0.456
4q72FADBifunctional protein PutA/0.455
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1jhqPMONicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.452
2huqSAHDiphthine synthase/0.452
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
1ep3FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.451
2e07SAHDiphthine synthase/0.451
3ibqATPPyridoxal kinase/0.451
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.451
2znpK55Peroxisome proliferator-activated receptor delta/0.450
3l63CAMCamphor 5-monooxygenase1.14.15.10.450
4ejmNAPPutative zinc-binding dehydrogenase/0.450
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.448
1xe55FEPlasmepsin-23.4.23.390.445
2a94AP0L-lactate dehydrogenase1.1.1.270.445
2ed5SAHDiphthine synthase/0.445
3d7kD7KBenzaldehyde lyase/0.445
3h8bNSYCathepsin L13.4.22.150.445
3wrhCAMCamphor 5-monooxygenase1.14.15.10.445
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.445
1bil0IURenin3.4.23.150.444
1sowNADL-lactate dehydrogenase1.1.1.270.444
3b70NAPEnoyl reductase LovC10.444
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.444
1o76CAMCamphor 5-monooxygenase1.14.15.10.443
2xfsJ01Uncharacterized protein/0.443
2z6rSAHDiphthine synthase/0.443
4bfxZVXPantothenate kinase2.7.1.330.443
4q73FADBifunctional protein PutA/0.443
3djjFADGlutathione reductase, mitochondrial1.8.1.70.442
3kb1ADPIron-sulfur cluster carrier protein/0.442
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.442
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.442
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
4j49NAIUncharacterized protein/0.442
1dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2fy4COACholine O-acetyltransferase2.3.1.60.441
4gxs0YSGlutamate receptor 2/0.441
1rfvADPPyridoxal kinase2.7.1.350.440
2a1oCAMCamphor 5-monooxygenase1.14.15.10.440
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.440
3mdmFJZCholesterol 24-hydroxylase/0.440