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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1c72EPYGlutathione S-transferase 22.5.1.18

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1c72EPYGlutathione S-transferase 22.5.1.181.000
1gsuGTXGlutathione S-transferase 22.5.1.180.624
5fwgGPRGlutathione S-transferase Mu 12.5.1.180.624
4gstGTDGlutathione S-transferase Mu 12.5.1.180.617
2gstGPSGlutathione S-transferase Mu 12.5.1.180.596
6gswGPSGlutathione S-transferase Mu 12.5.1.180.585
3gstGPRGlutathione S-transferase Mu 12.5.1.180.581
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.472
2gr1FADFerredoxin reductase/0.468
4n3e2ANPhenolic oxidative coupling protein/0.466
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
4h4xFADBiphenyl dioxygenase ferredoxin reductase subunit/0.464
1wvxBD4Death-associated protein kinase 12.7.11.10.462
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.462
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
1fvv107Cyclin-dependent kinase 22.7.11.220.458
2izrBRKCasein kinase I isoform gamma-32.7.11.10.458
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.458
5dpvSKEAurora kinase A2.7.11.10.457
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
3nux3NVCyclin-dependent kinase 62.7.11.220.455
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.451
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3ezrEZRCyclin-dependent kinase 22.7.11.220.450
3v04V04Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.450
1me7RVPInosine-5'-monophosphate dehydrogenase/0.449
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3zewSTUEphrin type-B receptor 42.7.10.10.449
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
1kvoOAPPhospholipase A2, membrane associated/0.448
1tj2FADBifunctional protein PutA1.5.5.20.448
1yvj4STTyrosine-protein kinase JAK32.7.10.20.448
3at4CCKCasein kinase II subunit alpha2.7.11.10.448
4g170VNCasein kinase I isoform gamma-32.7.11.10.448
4h50NAPBiphenyl dioxygenase ferredoxin reductase subunit/0.448
1kijNOVDNA gyrase subunit B/0.447
1n07FMNRiboflavin kinase2.7.1.260.447
1uadGNPRas-related protein Ral-A/0.447
2ckeIQUDeath-associated protein kinase 2/0.447
2vu3LZECyclin-dependent kinase 22.7.11.220.447
4gt3ATPMitogen-activated protein kinase 12.7.11.240.447
1ijjLARActin, alpha skeletal muscle/0.446
1jf7TBHTyrosine-protein phosphatase non-receptor type 13.1.3.480.446
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3au8NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.446
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3qp0NI8Gag-Pol polyprotein3.4.23.160.444
3upjU03Gag-Pol polyprotein/0.444
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.444
4dtaADNAPH(2'')-Id/0.444
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.443
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.443
3rgaLSBEpoxide hydrolase LasB5.5.10.443
3sjhLARActin, alpha skeletal muscle/0.443
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.443
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.443
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4a6cQG9Gag-Pol polyprotein3.4.23.160.442
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.442
1wvySTUDeath-associated protein kinase 12.7.11.10.441
2ijmADPFocal adhesion kinase 12.7.10.20.441
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.441
3sfuRBVPolyprotein/0.441
4px9ADPATP-dependent RNA helicase DDX3X3.6.4.130.441
4upjU04Gag-Pol polyprotein/0.441
5auzGENDeath-associated protein kinase 12.7.11.10.441
1gij2PUCyclin-dependent kinase 22.7.11.220.440
1tu8GTXGlutathione S-transferase 22.5.1.180.440
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.440
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3kddJZQGag-Pol polyprotein3.4.23.160.440
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4iwyADPRibosomal protein S6--L-glutamate ligase/0.440
4jrnANPRhoptry kinase family protein/0.440
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.440