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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1axgNADAlcohol dehydrogenase E chain1.1.1.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1axgNADAlcohol dehydrogenase E chain1.1.1.11.000
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.651
4ng5NAJAlcohol dehydrogenase E chain1.1.1.10.650
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.643
4nfhNAJAlcohol dehydrogenase E chain1.1.1.10.628
1adbCNDAlcohol dehydrogenase E chain1.1.1.10.619
1a71NADAlcohol dehydrogenase E chain1.1.1.10.611
1ht0NADAlcohol dehydrogenase 1C1.1.1.10.610
2jhfNADAlcohol dehydrogenase E chain1.1.1.10.610
1adcPADAlcohol dehydrogenase E chain1.1.1.10.603
1hszNADAlcohol dehydrogenase 1B1.1.1.10.603
1u3vNADAlcohol dehydrogenase 1B1.1.1.10.593
1mgoNADAlcohol dehydrogenase E chain1.1.1.10.589
2oxiNADAlcohol dehydrogenase E chain1.1.1.10.587
5cdsNAJAlcohol dehydrogenase E chain1.1.1.10.581
1axeNADAlcohol dehydrogenase E chain1.1.1.10.576
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.576
1agnNADAlcohol dehydrogenase class 4 mu/sigma chain1.1.1.10.554
4dlbNADS-(hydroxymethyl)glutathione dehydrogenase/0.552
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.504
1ma0NADAlcohol dehydrogenase class-31.1.1.10.502
2fzeAPRAlcohol dehydrogenase class-31.1.1.10.493
4cpdNADAlcohol dehydrogenase/0.491
1e3lNADAlcohol dehydrogenase 41.1.1.10.489
1cdoNADAlcohol dehydrogenase 11.1.1.10.488
4gl4NAIAlcohol dehydrogenase class-3/0.487
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.483
3ukoNADAlcohol dehydrogenase class-3/0.471
4jjiNADAlcohol dehydrogenase class-3/0.470
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.465
5kjfNAJAlcohol dehydrogenase E chain1.1.1.10.465
1hdzNADAlcohol dehydrogenase 1B1.1.1.10.463
1p0fNAPNADP-dependent alcohol dehydrogenase1.1.1.20.457
4dxhNAJAlcohol dehydrogenase E chain1.1.1.10.453
2xaaNADSecondary alcohol dehydrogenase/0.452
4c4oNADSADH/0.449
1r37NADNAD-dependent alcohol dehydrogenase1.1.1.10.442