sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 1.000 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.498 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.496 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.492 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.489 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.489 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.486 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.484 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.479 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.479 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.478 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.478 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.477 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.477 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.476 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.474 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.472 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.472 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.470 | |
| 1iy8 | NAD | Levodione reductase | / | 0.469 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.469 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.468 | |
| 1sny | NAP | LD36273p | / | 0.468 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.468 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.468 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.468 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.467 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.467 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.467 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.466 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.465 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.464 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.462 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.461 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.461 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.460 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.458 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.458 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.458 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.456 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.456 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.456 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.456 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.456 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.455 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.455 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.454 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.454 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.453 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.452 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.452 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.452 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.451 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.451 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.450 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.450 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.450 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.449 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.448 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.446 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.446 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.445 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.445 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.443 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.443 | |
| 3sju | NDP | Keto reductase | / | 0.443 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.443 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.442 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.441 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.440 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.440 |