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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5fs8FADApoptosis-inducing factor 1, mitochondrial1.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5fs8FADApoptosis-inducing factor 1, mitochondrial1.1.11.000
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.567
4bv6FADApoptosis-inducing factor 1, mitochondrial1.1.10.561
4liiFADApoptosis-inducing factor 1, mitochondrial1.1.10.549
1gv4FADApoptosis-inducing factor 1, mitochondrial1.1.10.540
3gd3FADApoptosis-inducing factor 1, mitochondrial1.1.10.540
5fs6FADApoptosis-inducing factor 1, mitochondrial1.1.10.533
2gr3FADFerredoxin reductase/0.501
4h4sFADBiphenyl dioxygenase ferredoxin reductase subunit/0.483
4h4pFADBiphenyl dioxygenase ferredoxin reductase subunit/0.482
4h4vFADBiphenyl dioxygenase ferredoxin reductase subunit/0.472
3lb8FADPutidaredoxin reductase1.18.1.50.471
3ef6FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.470
4h50FADBiphenyl dioxygenase ferredoxin reductase subunit/0.461
4emjFADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.460
3lxdFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.458
1m6iFADApoptosis-inducing factor 1, mitochondrial1.1.10.441