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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5dpvSKEAurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5dpvSKEAurora kinase A2.7.11.11.000
5dr6SKEAurora kinase A2.7.11.10.663
5dt0SKEAurora kinase A2.7.11.10.620
5dr9SKEAurora kinase A2.7.11.10.605
2dwbANPAurora kinase A2.7.11.10.530
4o0wADNAurora kinase A2.7.11.10.526
4jajXU1Aurora kinase A2.7.11.10.525
4deaNHIAurora kinase A2.7.11.10.519
2w1fL0FAurora kinase A2.7.11.10.516
3k5uPFQAurora kinase A2.7.11.10.511
2x6dX6DAurora kinase A2.7.11.10.509
2np8CC3Aurora kinase A2.7.11.10.495
2xru400Aurora kinase A2.7.11.10.494
1ol5ADPAurora kinase A2.7.11.10.484
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.483
5dosATPAurora kinase A2.7.11.10.482
5drdATPAurora kinase A2.7.11.10.479
4o0sADNAurora kinase A2.7.11.10.477
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.472
4jboWPHAurora kinase A2.7.11.10.470
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
1pxpCK8Cyclin-dependent kinase 22.7.11.220.468
4deeADPAurora kinase A2.7.11.10.468
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.466
3uo50BXAurora kinase A2.7.11.10.466
4hvi19STyrosine-protein kinase JAK32.7.10.20.466
5dt3ATPAurora kinase A2.7.11.10.466
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.465
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.464
1ol7ADPAurora kinase A2.7.11.10.462
4hvh19RTyrosine-protein kinase JAK32.7.10.20.461
4utdACPAurora kinase A2.7.11.10.461
4jbpYPHAurora kinase A2.7.11.10.460
5dn3ATPAurora kinase A2.7.11.10.460
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
4hvg19QTyrosine-protein kinase JAK32.7.10.20.459
3w18N13Aurora kinase A2.7.11.10.455
3zep1NXTyrosine-protein kinase JAK32.7.10.20.455
1u54ACPActivated CDC42 kinase 1/0.454
4bbfO19Tyrosine-protein kinase JAK2/0.453
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.453
4o0uADNAurora kinase A2.7.11.10.453
1t7i017Gag-Pol polyprotein3.4.23.160.452
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.452
3w16P9JAurora kinase A2.7.11.10.452
1xl5190Gag-Pol polyprotein3.4.23.160.451
1xddAAYIntegrin alpha-L/0.450
4qgiROCGag-Pol polyprotein3.4.23.160.450
3eb0DRKUncharacterized protein/0.449
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2vv9IM9Cyclin-dependent kinase 22.7.11.220.448
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.448
3s43478Protease/0.448
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.448
1yvj4STTyrosine-protein kinase JAK32.7.10.20.447
2eufLQQCyclin-dependent kinase 62.7.11.220.447
3ogqAB1Pol polyprotein/0.447
1bdlIM1Gag-Pol polyprotein3.4.23.160.446
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.446
4acm7YGCyclin-dependent kinase 22.7.11.220.446
4aqc88ATyrosine-protein kinase JAK2/0.446
5dnrATPAurora kinase A2.7.11.10.446
1a940Q4Gag-Pol polyprotein3.4.23.160.445
1bdrIM1Gag-Pol polyprotein3.4.23.160.445
1sbgIM1Gag-Pol polyprotein/0.445
2w1eL0EAurora kinase A2.7.11.10.445
4dpuAGSMevalonate diphosphate decarboxylase/0.445
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2qnpQN2Gag-Pol polyprotein3.4.23.160.444
3iok1P6Tyrosine-protein kinase JAK2/0.444
4fkr45KCyclin-dependent kinase 22.7.11.220.444
4wsqKSAAP2-associated protein kinase 12.7.11.10.444
1xjdSTUProtein kinase C theta type2.7.11.130.443
2b7aIZATyrosine-protein kinase JAK2/0.443
2r3kSCQCyclin-dependent kinase 22.7.11.220.443
4jbqVX6Aurora kinase A2.7.11.10.443
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.442
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.442
3be9P04Casein kinase II subunit alpha2.7.11.10.442
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.442
1d4kPI8Gag-Pol polyprotein3.4.23.160.441
2pvhP19Casein kinase II subunit alpha2.7.11.10.441
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.441
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.441
4i8zG08Gag-Pol polyprotein3.4.23.160.441
1y91CT9Cyclin-dependent kinase 22.7.11.220.440
2bqvA1AProtease/0.440
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.440
4c3rACPAurora kinase A2.7.11.10.440