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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5ainQMRSoluble acetylcholine receptor

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5ainQMRSoluble acetylcholine receptor/1.000
4bqtC5ESoluble acetylcholine receptor/0.516
2xytTC9Soluble acetylcholine receptor/0.491
2xnvVU3Soluble acetylcholine receptor/0.481
4alxIZNAcetylcholine-binding protein/0.481
3zdhXRSAcetylcholine-binding protein/0.475
2x9dITCTetracycline repressor protein class D/0.473
1kkq471Peroxisome proliferator-activated receptor alpha/0.471
3wtjTH4Acetylcholine-binding protein/0.465
4oztP1AEcdysone receptor, putative/0.463
5ch7MD1DMSO reductase family type II enzyme, molybdopterin subunit/0.462
2wo7ASVIsopenicillin N synthase1.21.3.10.460
4xwtU5PRibonuclease J/0.460
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.459
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.459
4ead0NPThymidine phosphorylase2.4.2.40.459
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.458
1obnASVIsopenicillin N synthase1.21.3.10.457
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
4kqqVPPPeptidoglycan D,D-transpeptidase FtsI/0.452
3k4nFADPyranose 2-oxidase/0.451
3u8m09RAcetylcholine-binding protein/0.451
1jqdSAHHistamine N-methyltransferase2.1.1.80.449
1uyfPU1Heat shock protein HSP 90-alpha/0.449
2y6fM9FIsopenicillin N synthase1.21.3.10.449
3lqfNADGalactitol dehydrogenase/0.449
1mp0NADAlcohol dehydrogenase class-31.1.1.10.448
2uxoTACHTH-type transcriptional regulator TtgR/0.448
1xddAAYIntegrin alpha-L/0.447
3o96IQORAC-alpha serine/threonine-protein kinase2.7.11.10.447
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.447
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.447
2y01Y00Beta-1 adrenergic receptor/0.446
3bhrTHGThymidylate synthase/0.446
3u8k09PAcetylcholine-binding protein/0.446
5e7oMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.446
3wipACHAcetylcholine-binding protein/0.445
4b5dSW4Achbp/0.445
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1xefATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.444
2bu9HFVIsopenicillin N synthase1.21.3.10.444
2vcmM11Isopenicillin N synthase1.21.3.10.444
3inxJZCHeat shock protein HSP 90-alpha/0.444
2o12FMNChorismate synthase/0.443
2xluNA7Putative flavin-containing monooxygenase/0.443
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.443
1qiqACCIsopenicillin N synthase1.21.3.10.442
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4ips1G4Mycocyclosin synthase1.14.21.90.442
4o1mNADEnoyl-acyl carrier reductase/0.442
1bq1CB3Thymidylate synthase/0.441
1n5qTNCActVA 6 protein/0.441
1x1bSAHC-20 methyltransferase/0.441
3ekuCY9Actin-5C/0.441
3zdgXRXAcetylcholine-binding protein/0.441
4ipw1G7Mycocyclosin synthase1.14.21.90.441
4psbGA3Cytokinin-specific binding protein/0.441
1k7fIAVTryptophan synthase alpha chain/0.440
1x1dSAHC-20 methyltransferase/0.440
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.440
2vbpVB1Isopenicillin N synthase1.21.3.10.440
2y60M8FIsopenicillin N synthase1.21.3.10.440
3iocA5DPantothenate synthetase6.3.2.10.440