sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4z87 | 5GP | Inosine-5'-monophosphate dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4z87 | 5GP | Inosine-5'-monophosphate dehydrogenase | / | 1.000 | |
| 4z0g | 5GP | Inosine-5'-monophosphate dehydrogenase | / | 0.607 | |
| 2cu0 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.565 | |
| 1nf7 | RVP | Inosine-5'-monophosphate dehydrogenase 2 | / | 0.548 | |
| 1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.519 | |
| 1me8 | RVP | Inosine-5'-monophosphate dehydrogenase | / | 0.504 | |
| 1me7 | RVP | Inosine-5'-monophosphate dehydrogenase | / | 0.491 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.478 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.466 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.466 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.461 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.459 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.458 | |
| 2a1y | 5GP | GMP reductase | / | 0.456 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.456 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.455 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.453 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.453 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.452 | |
| 2qn7 | HBZ | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.451 | |
| 1gqt | ACP | Ribokinase | / | 0.450 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.450 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.450 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.449 | |
| 1xah | NAD | 3-dehydroquinate synthase | / | 0.449 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.449 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 5a3b | APR | SIR2 family protein | / | 0.448 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.447 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.447 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.446 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.445 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 3ms4 | 21N | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.445 | |
| 1osv | CHC | Bile acid receptor | / | 0.444 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.444 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.444 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.444 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.443 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.442 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.442 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.442 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.441 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.441 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.441 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 |