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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4wujFMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4wujFMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy/1.000
3hjiFADVivid PAS protein VVD/0.593
2pd7FADVivid PAS protein VVD/0.573
3d72FADVivid PAS protein VVD/0.558
3hjkFADVivid PAS protein VVD/0.556
1n9lFMNPutative blue light receptor/0.551
2pd8FADVivid PAS protein VVD/0.551
2z6dFMNPhototropin-22.7.11.10.550
2pdtFADVivid PAS protein VVD/0.545
3is2FADVivid PAS protein VVD/0.544
1n9nFMNPutative blue light receptor/0.539
4r38RBFBlue-light-activated histidine kinase 22.7.13.30.535
2pr5FMNBlue-light photoreceptor/0.522
4xj3GTPCyclic GMP-AMP synthase/0.521
4hj4FMNLOV protein/0.516
4eetFMNPhototropin-22.7.11.10.509
4hhdFMNPhototropin-12.7.11.10.501
2z6cFMNPhototropin-12.7.11.10.496
5j3wFMNSensory box protein/0.496
3t50FMNBlue-light-activated histidine kinase2.7.13.30.495
4eeuFMNPhototropin-22.7.11.10.494
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.490
4hj6FMNLOV protein/0.489
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.488
5djtFMNNPH1-2/0.488
5djuFMNNPH1-2/0.488
3ue6FMNAureochrome1/0.487
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.482
4hiaFMNLOV protein/0.482
4hnbFMNLOV protein/0.477
3wfjNAD2-dehydropantoate 2-reductase/0.476
4r3aRBFBlue-light-activated histidine kinase 22.7.13.30.476
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.475
4u03GTPCyclic GMP-AMP synthase/0.474
2dcnADP2-keto-3-deoxy-gluconate kinase/0.473
3p7nFMNLight-activated DNA-binding protein EL222/0.470
5j4eFMNSensory box protein/0.470
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.468
4a4wYFBPeroxisome proliferator-activated receptor gamma/0.467
2q5g1FAPeroxisome proliferator-activated receptor delta/0.466
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.465
4lfiGNPCasein kinase II subunit alpha2.7.11.10.463
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.462
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.461
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.461
1iyzNDPProbable quinone oxidoreductase/0.460
3sw1FMNSensory box protein/0.460
4hj3FMNLOV protein/0.460
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.459
3k5uPFQAurora kinase A2.7.11.10.459
4o3mADPBloom syndrome protein3.6.4.120.459
2q61SF1Peroxisome proliferator-activated receptor gamma/0.458
4qecNAPElxO/0.458
1a72PADAlcohol dehydrogenase E chain1.1.1.10.457
1adfTADAlcohol dehydrogenase E chain1.1.1.10.457
2ji8FYNOxalyl-CoA decarboxylase4.1.1.80.457
3icrCOACoenzyme A disulfide reductase/0.457
3triNAPPyrroline-5-carboxylate reductase/0.457
3vthAPCCarbamoyltransferase/0.457
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.456
3almFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.456
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.456
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.456
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.454
3och2MXDihydrofolate reductase1.5.1.30.454
4dqwATPInosine-5'-monophosphate dehydrogenase/0.454
4yswFADXanthine dehydrogenase/oxidase/0.454
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.454
1xkdNAPIsocitrate dehydrogenase [NADP]/0.453
1tj0FADBifunctional protein PutA1.5.5.20.452
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.451
4deeADPAurora kinase A2.7.11.10.451
5cnoANPEpidermal growth factor receptor2.7.10.10.451
1y4lSVRBasic phospholipase A2 homolog 2/0.450
3rusADPChaperonin/0.449
4jbpYPHAurora kinase A2.7.11.10.449
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4bfsZVSPantothenate kinase2.7.1.330.448
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
4o4fATPKinase/0.448
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.447
2hw1ANPKetohexokinase/0.447
3a4vNADNDP-sugar epimerase/0.447
3nbvANPKetohexokinase/0.447
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.447
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4hee14RPeroxisome proliferator-activated receptor gamma/0.447
4jy2FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.447
4xf7ACPCarbohydrate/pyrimidine kinase, PfkB family/0.447
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
2c3qGTXGlutathione S-transferase theta-12.5.1.180.446
2q59240Peroxisome proliferator-activated receptor gamma/0.446
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1ipeNDPTropinone reductase 21.1.1.2360.445
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.445
1sxjADPReplication factor C subunit 5/0.445
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.445
1zeoC01Peroxisome proliferator-activated receptor gamma/0.445
3cgfJNFMitogen-activated protein kinase 102.7.11.240.445
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.445
3nwyGTPUridylate kinase/0.445
3ortAGSSerine/threonine protein kinase/0.445
5cnnANPEpidermal growth factor receptor2.7.10.10.445
1d4hBEHGag-Pol polyprotein3.4.23.160.444
2p4yC03Peroxisome proliferator-activated receptor gamma/0.444
2qa1FADPgaE/0.444
2qa2FADPolyketide oxygenase CabE/0.444
4bfxZVXPantothenate kinase2.7.1.330.444
4em9TCEPeroxisome proliferator-activated receptor gamma/0.444
4fxfATPPyruvate kinase PKM2.7.1.400.444
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.444
1mrwK57Gag-Pol polyprotein3.4.23.160.443
3em6017Gag-Pol polyprotein3.4.23.160.443
4anmWULCasein kinase II subunit alpha2.7.11.10.443
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.443
4xumIMNPeroxisome proliferator-activated receptor gamma/0.443
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.443
1fnnADPORC1-type DNA replication protein/0.442
2p33J07Mitogen-activated protein kinase 102.7.11.240.442
4e07ACPPlasmid partitioning protein ParF/0.442
4f07FADStyrene monooxygenase component 2/0.442
1rywEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.441
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.441
2gn8NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.441
2q5p241Peroxisome proliferator-activated receptor gamma/0.441
3icsCOACoenzyme A disulfide reductase/0.441
3lu7IPXSerum albumin/0.441
3of4FMNNitroreductase/0.441
4c58824Cyclin-G-associated kinase2.7.11.10.441
4zohFADPutative oxidoreductase FAD-binding subunit/0.441
1draMTXDihydrofolate reductase1.5.1.30.440
1i3mUD1UDP-glucose 4-epimerase/0.440
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.440
3ekx1UNGag-Pol polyprotein3.4.23.160.440
3h0aD30Peroxisome proliferator-activated receptor gamma/0.440
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.440