sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4tln | LNO | Thermolysin | 3.4.24.27 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4tln | LNO | Thermolysin | 3.4.24.27 | 1.000 | |
| 2tmn | 0FA | Thermolysin | 3.4.24.27 | 0.789 | |
| 6tmn | 0PI | Thermolysin | 3.4.24.27 | 0.767 | |
| 4tmn | 0PK | Thermolysin | 3.4.24.27 | 0.669 | |
| 3t8d | UBV | Thermolysin | 3.4.24.27 | 0.665 | |
| 3t8h | UBS | Thermolysin | 3.4.24.27 | 0.658 | |
| 4h57 | 0PJ | Thermolysin | 3.4.24.27 | 0.649 | |
| 3t74 | UBY | Thermolysin | 3.4.24.27 | 0.648 | |
| 3for | ZNP | Thermolysin | 3.4.24.27 | 0.608 | |
| 4d9w | X32 | Thermolysin | 3.4.24.27 | 0.608 | |
| 3t87 | UBZ | Thermolysin | 3.4.24.27 | 0.601 | |
| 3t8c | UBW | Thermolysin | 3.4.24.27 | 0.598 | |
| 1qf2 | TI3 | Thermolysin | 3.4.24.27 | 0.593 | |
| 3fgd | BYA | Thermolysin | 3.4.24.27 | 0.585 | |
| 4b52 | RDF | Bacillolysin | / | 0.558 | |
| 3f28 | S7B | Thermolysin | 3.4.24.27 | 0.534 | |
| 3f2p | S3B | Thermolysin | 3.4.24.27 | 0.495 | |
| 4ca5 | 3EF | Angiotensin-converting enzyme | 3.2.1 | 0.480 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.473 | |
| 4zr5 | RDF | Neprilysin | / | 0.470 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.465 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.462 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.460 | |
| 4ca7 | 3EF | Angiotensin-converting enzyme | 3.4.15.1 | 0.456 | |
| 3kds | NHX | ATP-dependent zinc metalloprotease FtsH | / | 0.455 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.454 | |
| 4fry | NAD | Putative signal-transduction protein with CBS domains | / | 0.454 | |
| 4jic | FMN | GTN Reductase | / | 0.453 | |
| 4h1q | 0XX | Matrix metalloproteinase-9 | 3.4.24.35 | 0.451 | |
| 4xfj | ANP | Argininosuccinate synthase | / | 0.451 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.450 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.449 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.449 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.448 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.445 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.444 | |
| 3suf | SUE | Polyprotein | / | 0.444 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 1sve | I01 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.442 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3nxq | RX4 | Angiotensin-converting enzyme | 3.2.1 | 0.441 | |
| 4bk2 | FAD | Probable salicylate monooxygenase | / | 0.441 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.441 | |
| 5aga | ANP | DNA polymerase theta | / | 0.441 | |
| 1eio | GCH | Gastrotropin | / | 0.440 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.440 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.440 |