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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4o4lGTPTubulin alpha-1B chain

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4o4lGTPTubulin alpha-1B chain/1.000
4tv9GTPTubulin alpha-1B chain/0.629
4wbnGTPTubulin alpha-1B chain/0.613
4ihjGTPTubulin alpha-1B chain/0.609
5jqgGTPTubulin alpha-1B chain/0.607
4o4iGTPTubulin alpha-1B chain/0.606
4zolGTPTubulin alpha-1B chain/0.605
4iijGTPTubulin alpha-1B chain/0.600
3ryhGTPTubulin alpha chain/0.561
4tuyGTPTubulin alpha-1B chain/0.547
4ffbGTPTubulin alpha-1 chain/0.539
5la6GTPTubulin alpha-1B chain/0.533
4u3jGTPTubulin beta chain/0.530
4yj2GTPTubulin alpha-1B chain/0.507
5itzGTPTubulin alpha-1B chain/0.473
2b4qNAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.469
4f6rGDPTubulin beta chain/0.466
2gjlFMNNitronate monooxygenase1.13.12.160.465
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.455
3pduNAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase/0.454
1giaGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.453
1il0NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.453
4lcjNADC-terminal-binding protein 2/0.450
3f63GTXGlutathione transferase GST1-4/0.448
2ebaFADPutative glutaryl-CoA dehydrogenase/0.447
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.447
3nbvANPKetohexokinase/0.445
2ylrNAPPhenylacetone monooxygenase1.14.13.920.444
3pefNAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase/0.444
1xe55FEPlasmepsin-23.4.23.390.443
3wczNAPAldo-keto reductase AKR2E4/0.443
3zidGDPTubulin-like protein CetZ/0.443
3w2eNADNADH-cytochrome b5 reductase 31.6.2.20.441
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.440
3gwdNAPCyclohexanone monooxygenase/0.440
4d5gFADCyclohexane-1,2-dione hydrolase3.7.1.110.440