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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4nmkNAPAldehyde dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4nmkNAPAldehyde dehydrogenase/1.000
4nmjNAPAldehyde dehydrogenase/0.646
4h73NDPAldehyde dehydrogenase/0.582
1bxsNADRetinal dehydrogenase 11.2.1.360.517
2d4eNAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831]/0.511
4i1wNAD2-aminomuconate 6-semialdehyde dehydrogenase/0.508
4oe2NAD2-aminomuconate 6-semialdehyde dehydrogenase/0.505
2j40NAD1-pyrroline-5-carboxylate dehydrogenase/0.503
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.503
4v37NADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.501
2bjaNAD1-pyrroline-5-carboxylate dehydrogenase/0.491
2ehqNAP1-pyrroline-5-carboxylate dehydrogenase/0.490
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.483
1nzxNADAldehyde dehydrogenase, mitochondrial1.2.1.30.481
2ehuNAD1-pyrroline-5-carboxylate dehydrogenase/0.480
4wb9NAIRetinal dehydrogenase 11.2.1.360.480
3iwkNADAminoaldehyde dehydrogenase/0.473
2bhpNAD1-pyrroline-5-carboxylate dehydrogenase/0.472
5eyuNADBetaine-aldehyde dehydrogenase/0.470
4fqfNADAldehyde dehydrogenase, mitochondrial1.2.1.30.467
2eiiNAD1-pyrroline-5-carboxylate dehydrogenase/0.466
4pz2NADAldehyde dehydrogenase 2-6/0.465
2esdNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase1.2.1.90.464
3n82NADAldehyde dehydrogenase, mitochondrial1.2.1.30.462
1o02NADAldehyde dehydrogenase, mitochondrial1.2.1.30.459
4a0mNADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.458
1nzzNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.455
2wmeNAPNAD/NADP-dependent betaine aldehyde dehydrogenase/0.455
3rhhNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase/0.453
1bpwNADBetaine aldehyde dehydrogenase1.2.1.80.450
4i3vNADAldehyde dehydrogenase (NAD+)/0.449
4x4lNAIRetinal dehydrogenase 11.2.1.360.449
4pxlNADAldehyde dehydrogenase3/0.447
1cw3NADAldehyde dehydrogenase, mitochondrial1.2.1.30.444
3n83ADPAldehyde dehydrogenase, mitochondrial1.2.1.30.444
3iwjNADAminoaldehyde dehydrogenase/0.440