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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.261.000
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.736
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.660
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.656
3du8553Glycogen synthase kinase-3 beta2.7.11.260.545
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.541
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.521
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.517
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.515
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.514
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.511
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.510
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.510
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.506
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.498
4ii5ADPCyclin-dependent kinase 22.7.11.220.496
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.494
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.490
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.489
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.485
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.481
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.480
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.480
2qo9ANPEphrin type-A receptor 32.7.10.10.479
4riyADPEpidermal growth factor receptor2.7.10.10.479
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.477
4jrnANPRhoptry kinase family protein/0.477
4eooATPCyclin-dependent kinase 22.7.11.220.476
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.472
4qnyANPMitogen activated protein kinase, putative/0.472
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.470
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.470
1gy3ATPCyclin-dependent kinase 22.7.11.220.468
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.467
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.467
4bgg844Activin receptor type-12.7.11.300.467
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.467
2acxANPG protein-coupled receptor kinase 62.7.11.160.466
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.465
1qmzATPCyclin-dependent kinase 22.7.11.220.464
2py3ACPFibroblast growth factor receptor 2/0.464
4wboANWRhodopsin kinase/0.464
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.462
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.462
2cchATPCyclin-dependent kinase 22.7.11.220.461
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.461
1hk1T44Serum albumin/0.460
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.460
2bxnIDBSerum albumin/0.459
1hk3T44Serum albumin/0.458
3qc9ADPRhodopsin kinase/0.457
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.457
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.456
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.456
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.456
4g2fC07Ephrin type-A receptor 32.7.10.10.456
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.455
2pzpACPFibroblast growth factor receptor 2/0.455
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.455
4i3zADPCyclin-dependent kinase 22.7.11.220.455
4qo9627Serine/threonine-protein kinase 242.7.11.10.455
3a7jADPSerine/threonine-protein kinase 242.7.11.10.454
4qmlANPSerine/threonine-protein kinase 242.7.11.10.454
2c6eHPMAurora kinase A2.7.11.10.453
2pmlANPUncharacterized protein/0.453
3a60STURibosomal protein S6 kinase beta-12.7.11.10.453
4bbe3O4Tyrosine-protein kinase JAK2/0.453
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.453
3blqATPCyclin-dependent kinase 92.7.11.220.452
3c4wATPRhodopsin kinase/0.452
3c50ADPRhodopsin kinase/0.452
1m17AQ4Epidermal growth factor receptor2.7.10.10.451
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.451
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.451
4dymIYZActivin receptor type-12.7.11.300.451
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.450
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.450
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.450
1u54ACPActivated CDC42 kinase 1/0.449
4jia1K3Tyrosine-protein kinase JAK2/0.449
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.449
4xlvACPInsulin receptor2.7.10.10.449
2qoqANPEphrin type-A receptor 32.7.10.10.448
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.448
4qmySTUSerine/threonine-protein kinase 242.7.11.10.448
3clyACPFibroblast growth factor receptor 2/0.447
3nnuEDBMitogen-activated protein kinase 14/0.447
3wowANPCasein kinase II subunit alpha2.7.11.10.447
1jstATPCyclin-dependent kinase 22.7.11.220.446
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.446
4enhFVXCholesterol 24-hydroxylase/0.446
4k33ACPFibroblast growth factor receptor 32.7.10.10.446
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.446
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.445
2hog710Serine/threonine-protein kinase Chk12.7.11.10.445
2pz5ACPFibroblast growth factor receptor 2/0.445
2qocANPEphrin type-A receptor 32.7.10.10.445
2henADPEphrin type-B receptor 22.7.10.10.444
2i0ePDSProtein kinase C beta type2.7.11.130.444
2qo7ANPEphrin type-A receptor 32.7.10.10.444
2xyuQ9GEphrin type-A receptor 42.7.10.10.444
1cm8ANPMitogen-activated protein kinase 12/0.443
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.443
3oriAGSSerine/threonine protein kinase/0.443
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.443
2ittAEEEpidermal growth factor receptor2.7.10.10.442
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.442
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.441
2xvdAS6Ephrin type-B receptor 42.7.10.10.441
3erkSB4Mitogen-activated protein kinase 12.7.11.240.441
4s33ANPMitogen-activated protein kinase 12.7.11.240.441
1lp4ANPCasein kinase II subunit alpha2.7.11.10.440
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.440
2bxiAZQSerum albumin/0.440
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.440
4gk2L66Ephrin type-A receptor 32.7.10.10.440
4jboWPHAurora kinase A2.7.11.10.440
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.440
4z69DIFSerum albumin/0.440