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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4l33F70Tankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4l33F70Tankyrase-22.4.2.301.000
4bu908CTankyrase-22.4.2.300.730
4bufF36Tankyrase-22.4.2.300.712
4l321VFTankyrase-22.4.2.300.675
4l0s1UZTankyrase-22.4.2.300.664
4avwG18Tankyrase-22.4.2.300.656
4l0i1UWTankyrase-22.4.2.300.654
4buuF38Tankyrase-22.4.2.300.653
3kr8XAVTankyrase-22.4.2.300.645
4iueAJ4Tankyrase-22.4.2.300.642
4l341VGTankyrase-22.4.2.300.637
4hkiFLNTankyrase-22.4.2.300.633
4hlf15ZTankyrase-22.4.2.300.633
4l2f1V3Tankyrase-22.4.2.300.631
4l31F08Tankyrase-22.4.2.300.631
4hlg20BTankyrase-22.4.2.300.628
4bueJQFTankyrase-22.4.2.300.626
4buiW2ETankyrase-22.4.2.300.626
4kzuA73Tankyrase-22.4.2.300.625
4buxF35Tankyrase-22.4.2.300.620
5aku29FTankyrase-22.4.2.300.620
4bus32FTankyrase-22.4.2.300.618
4hlm16STankyrase-22.4.2.300.616
4l0t1V0Tankyrase-22.4.2.300.616
4hkkAGITankyrase-22.4.2.300.612
4l2k1V8Tankyrase-22.4.2.300.612
4buv16ITankyrase-22.4.2.300.605
3p0pNNFTankyrase-22.4.2.300.603
4hlk431Tankyrase-22.4.2.300.601
4but31FTankyrase-22.4.2.300.598
4hmhF94Tankyrase-22.4.2.300.595
4j22AJ7Tankyrase-22.4.2.300.594
4hlh20DTankyrase-22.4.2.300.589
4buwF33Tankyrase-22.4.2.300.588
4hl515WTankyrase-22.4.2.300.588
4hknLU2Tankyrase-22.4.2.300.586
4l10A63Tankyrase-22.4.2.300.585
4j21AJ6Tankyrase-22.4.2.300.584
4bud29FTankyrase-22.4.2.300.581
4l0v1V1Tankyrase-22.4.2.300.575
4l2g1V4Tankyrase-22.4.2.300.574
4kzl20DTankyrase-22.4.2.300.566
4bs4A64Tankyrase-22.4.2.300.556
4bj9UHBTankyrase-22.4.2.300.555
3u9y09LTankyrase-22.4.2.300.554
4pnrG18Tankyrase-22.4.2.300.543
4tkg09LTankyrase-22.4.2.300.537
4krs1SXTankyrase-12.4.2.300.531
4msk2C8Tankyrase-12.4.2.300.531
4pnmNU1Tankyrase-22.4.2.300.520
4j3mAJ8Tankyrase-22.4.2.300.498
4bjbP34Tankyrase-22.4.2.300.497
4j3lAJ5Tankyrase-22.4.2.300.491
4l091URTankyrase-22.4.2.300.488
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.486
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.470
4tjy3GNTankyrase-22.4.2.300.469
4avuLDRTankyrase-22.4.2.300.467
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.467
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.462
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.460
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.456
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.455
4i9i1DYTankyrase-12.4.2.300.453
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.451
1amoFMNNADPH--cytochrome P450 reductase/0.447
3rsv3RSBeta-secretase 13.4.23.460.447
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.445
1x8lOXRRetinol dehydratase/0.444
1fmlRTLRetinol dehydratase/0.443
4dbs0HVAldo-keto reductase family 1 member C3/0.441
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.440