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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4koaNDP1,5-anhydro-D-fructose reductase1.1.1.292

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4koaNDP1,5-anhydro-D-fructose reductase1.1.1.2921.000
1h6cNDPGlucose--fructose oxidoreductase1.1.99.280.483
1ybaNADD-3-phosphoglycerate dehydrogenase1.1.1.950.474
1u4oNDDL-lactate dehydrogenase1.1.1.270.472
3sn6P0GBeta-2 adrenergic receptor/0.472
1h6bNDPGlucose--fructose oxidoreductase1.1.99.280.470
1kkq471Peroxisome proliferator-activated receptor alpha/0.468
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.467
4l8vNAPInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.466
4da7AC2Purine nucleoside phosphorylase DeoD-type2.4.2.10.464
1blzACVIsopenicillin N synthase1.21.3.10.463
3orfNADDihydropteridine reductase1.5.1.340.461
2ejvNADL-threonine 3-dehydrogenase/0.460
1obnASVIsopenicillin N synthase1.21.3.10.459
1evjNADGlucose--fructose oxidoreductase1.1.99.280.457
4zgsNADPutative D-lactate dehydrogenase/0.457
2y60M8FIsopenicillin N synthase1.21.3.10.456
2p9gNAID-3-phosphoglycerate dehydrogenase1.1.1.950.455
4q71FADBifunctional protein PutA/0.455
1xl2189Gag-Pol polyprotein3.4.23.160.453
2oapANPType II secretion system protein (GspE-2)/0.453
5a06NDPGlucose-fructose oxidoreductase/0.453
1ha3MAUElongation factor Tu-A/0.452
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1tehNADAlcohol dehydrogenase class-31.1.1.10.451
2q4bNAPUncharacterized protein At5g02240/0.451
3mdvCL6Cholesterol 24-hydroxylase/0.451
3p62FMNPentaerythritol tetranitrate reductase/0.451
1h6aNDPGlucose--fructose oxidoreductase1.1.99.280.449
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.449
2iviACWIsopenicillin N synthase1.21.3.10.449
3qvxNADMyo-inositol-1-phosphate synthase (Ino1)/0.449
4xmxBESAminopeptidase N3.4.11.20.449
1w06W05Isopenicillin N synthase1.21.3.10.448
2glxNDP1,5-anhydro-D-fructose reductase/0.448
4a99FADTetX family tetracycline inactivation enzyme/0.448
4dbzNDPPutative ketoacyl reductase1.3.10.448
1nzdUPGDNA beta-glucosyltransferase/0.447
1ryeNDPGlucose--fructose oxidoreductase1.1.99.280.447
2xb5I7TTetracycline repressor protein class D/0.447
3tqhNDPQuinone oxidoreductase/0.447
4da6GA2Purine nucleoside phosphorylase DeoD-type2.4.2.10.447
4jjiNADAlcohol dehydrogenase class-3/0.447
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.446
2fzwNADAlcohol dehydrogenase class-31.1.1.10.446
5fm7ADPRuvB-like helicase/0.446
1i5bANPChemotaxis protein CheA2.7.13.30.445
4x7wMVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.445
5a04NDPGlucose-fructose oxidoreductase/0.445
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.445
1j49NADD-lactate dehydrogenase1.1.1.280.444
1jkx138Phosphoribosylglycinamide formyltransferase/0.444
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
2q3rFMN12-oxophytodienoate reductase 11.3.1.420.444
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.444
4dc0NDPPutative ketoacyl reductase1.3.10.444
4h3g10QBeta-secretase 13.4.23.460.443
1e7qNAPGDP-L-fucose synthase/0.442
1ma0NADAlcohol dehydrogenase class-31.1.1.10.442
1dirNADDihydropteridine reductase1.5.1.340.441
1e3eNAIAlcohol dehydrogenase 41.1.1.10.441
3mjeNDPAmphB/0.440
4cdmFO1Deoxyribodipyrimidine photolyase/0.440
4e2bFMNDehydrogenase/0.440
5dozNDPJamJ/0.440