sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4jlt | 8PR | Cytochrome P450 2B4 | 1.14.14.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4jlt | 8PR | Cytochrome P450 2B4 | 1.14.14.1 | 1.000 | |
| 3qly | 55V | Uncharacterized protein | / | 0.482 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.474 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.469 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.464 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.461 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.459 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.457 | |
| 2vf0 | F89 | Thymidylate synthase | / | 0.455 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.455 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.455 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.455 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.454 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.454 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.454 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 1syn | F89 | Thymidylate synthase | / | 0.452 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.452 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3hl7 | I47 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.451 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1osv | CHC | Bile acid receptor | / | 0.450 | |
| 1v79 | FR7 | Adenosine deaminase | 3.5.4.4 | 0.450 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.448 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.448 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1bpj | UMP | Thymidylate synthase | / | 0.447 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.447 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.446 | |
| 3cse | N22 | Uncharacterized protein | / | 0.446 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.446 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.446 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.445 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.445 | |
| 3b89 | 5GP | 16S rRNA methylase | / | 0.445 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.445 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.445 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.444 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.444 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.444 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.444 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.443 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.443 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.443 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.442 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.442 | |
| 1xqc | AEJ | Estrogen receptor | / | 0.441 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.441 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.441 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.440 | |
| 4l9k | EHF | Serum albumin | / | 0.440 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.440 |