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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4j22AJ7Tankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4j22AJ7Tankyrase-22.4.2.301.000
4bud29FTankyrase-22.4.2.300.720
4l321VFTankyrase-22.4.2.300.693
4l0t1V0Tankyrase-22.4.2.300.669
4iueAJ4Tankyrase-22.4.2.300.663
4buxF35Tankyrase-22.4.2.300.660
4bueJQFTankyrase-22.4.2.300.648
4l2k1V8Tankyrase-22.4.2.300.648
4hkkAGITankyrase-22.4.2.300.638
4hlf15ZTankyrase-22.4.2.300.631
4bu908CTankyrase-22.4.2.300.630
4l0s1UZTankyrase-22.4.2.300.630
4j21AJ6Tankyrase-22.4.2.300.626
4l31F08Tankyrase-22.4.2.300.625
4l2f1V3Tankyrase-22.4.2.300.621
4l10A63Tankyrase-22.4.2.300.618
5aku29FTankyrase-22.4.2.300.617
4buuF38Tankyrase-22.4.2.300.616
4hlm16STankyrase-22.4.2.300.615
4l0v1V1Tankyrase-22.4.2.300.614
4l341VGTankyrase-22.4.2.300.611
4hl515WTankyrase-22.4.2.300.609
3kr8XAVTankyrase-22.4.2.300.608
4hlh20DTankyrase-22.4.2.300.607
4hlk431Tankyrase-22.4.2.300.607
4but31FTankyrase-22.4.2.300.606
4l33F70Tankyrase-22.4.2.300.606
4kzuA73Tankyrase-22.4.2.300.605
4bufF36Tankyrase-22.4.2.300.603
4l0i1UWTankyrase-22.4.2.300.603
4avwG18Tankyrase-22.4.2.300.602
4l2g1V4Tankyrase-22.4.2.300.602
4bus32FTankyrase-22.4.2.300.596
4buiW2ETankyrase-22.4.2.300.589
4hmhF94Tankyrase-22.4.2.300.588
4hlg20BTankyrase-22.4.2.300.586
4hknLU2Tankyrase-22.4.2.300.583
4kzl20DTankyrase-22.4.2.300.583
4buwF33Tankyrase-22.4.2.300.577
4bs4A64Tankyrase-22.4.2.300.575
3p0pNNFTankyrase-22.4.2.300.570
4tkg09LTankyrase-22.4.2.300.560
4msk2C8Tankyrase-12.4.2.300.556
4bjbP34Tankyrase-22.4.2.300.549
4pnrG18Tankyrase-22.4.2.300.549
4hkiFLNTankyrase-22.4.2.300.540
4j3lAJ5Tankyrase-22.4.2.300.540
4j3mAJ8Tankyrase-22.4.2.300.538
4bj9UHBTankyrase-22.4.2.300.535
4krs1SXTankyrase-12.4.2.300.524
4pnmNU1Tankyrase-22.4.2.300.524
4l091URTankyrase-22.4.2.300.514
4buv16ITankyrase-22.4.2.300.498
4avuLDRTankyrase-22.4.2.300.495
4hyf1AKTankyrase-22.4.2.300.493
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.486
4tjy3GNTankyrase-22.4.2.300.485
1x8lOXRRetinol dehydratase/0.482
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.469
4li81XQTankyrase-12.4.2.300.459
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.458
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.455
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.454
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.448
1fmlRTLRetinol dehydratase/0.446
3c4aFADProtodeoxyviolaceinate monooxygenase10.446
3qm4PN0Cytochrome P450 2D6/0.445
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.444
4li71XPTankyrase-12.4.2.300.444
1amoFMNNADPH--cytochrome P450 reductase/0.443
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.443
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.441
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.440