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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4iueAJ4Tankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4iueAJ4Tankyrase-22.4.2.301.000
3kr8XAVTankyrase-22.4.2.300.661
4l0i1UWTankyrase-22.4.2.300.648
4bueJQFTankyrase-22.4.2.300.641
4j21AJ6Tankyrase-22.4.2.300.639
4buxF35Tankyrase-22.4.2.300.638
4j22AJ7Tankyrase-22.4.2.300.633
4l0t1V0Tankyrase-22.4.2.300.628
4l10A63Tankyrase-22.4.2.300.626
4l33F70Tankyrase-22.4.2.300.626
4bufF36Tankyrase-22.4.2.300.624
4hlf15ZTankyrase-22.4.2.300.620
4l2f1V3Tankyrase-22.4.2.300.615
4l2k1V8Tankyrase-22.4.2.300.610
4bu908CTankyrase-22.4.2.300.609
4l31F08Tankyrase-22.4.2.300.607
4hkkAGITankyrase-22.4.2.300.605
4kzuA73Tankyrase-22.4.2.300.602
4l0v1V1Tankyrase-22.4.2.300.602
4hl515WTankyrase-22.4.2.300.601
4hmhF94Tankyrase-22.4.2.300.600
4kzl20DTankyrase-22.4.2.300.597
4bus32FTankyrase-22.4.2.300.596
4l2g1V4Tankyrase-22.4.2.300.596
4hknLU2Tankyrase-22.4.2.300.592
4l341VGTankyrase-22.4.2.300.592
4bud29FTankyrase-22.4.2.300.591
4l321VFTankyrase-22.4.2.300.591
4hlh20DTankyrase-22.4.2.300.590
4l0s1UZTankyrase-22.4.2.300.588
4hlk431Tankyrase-22.4.2.300.584
4hlm16STankyrase-22.4.2.300.584
3p0pNNFTankyrase-22.4.2.300.583
4buwF33Tankyrase-22.4.2.300.580
4bs4A64Tankyrase-22.4.2.300.578
4buuF38Tankyrase-22.4.2.300.577
5aku29FTankyrase-22.4.2.300.573
4but31FTankyrase-22.4.2.300.568
4tkg09LTankyrase-22.4.2.300.568
4hlg20BTankyrase-22.4.2.300.566
4buiW2ETankyrase-22.4.2.300.561
4krs1SXTankyrase-12.4.2.300.559
4avwG18Tankyrase-22.4.2.300.558
4bj9UHBTankyrase-22.4.2.300.547
4pnrG18Tankyrase-22.4.2.300.539
3u9y09LTankyrase-22.4.2.300.533
4l091URTankyrase-22.4.2.300.528
4hkiFLNTankyrase-22.4.2.300.522
4j3lAJ5Tankyrase-22.4.2.300.517
4bjbP34Tankyrase-22.4.2.300.505
4msk2C8Tankyrase-12.4.2.300.504
4pnmNU1Tankyrase-22.4.2.300.503
4j3mAJ8Tankyrase-22.4.2.300.500
4buv16ITankyrase-22.4.2.300.486
4avuLDRTankyrase-22.4.2.300.470
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.470
4tjy3GNTankyrase-22.4.2.300.464
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.455
2j83BATUlilysin3.4.240.453
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.453
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.451
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3tqcADPPantothenate kinase/0.443
4frkDWDBeta-secretase 13.4.23.460.443
1amoFMNNADPH--cytochrome P450 reductase/0.442
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.442
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.441
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.441
1q23FUAChloramphenicol acetyltransferase2.3.1.280.440
3vyfVYFRenin3.4.23.150.440