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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.17

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.171.000
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.516
3orpAGSSerine/threonine protein kinase/0.481
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.480
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.477
4fv6E57Mitogen-activated protein kinase 12.7.11.240.469
3c4xATPRhodopsin kinase/0.467
3c4zADPRhodopsin kinase/0.466
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.464
4qnyANPMitogen activated protein kinase, putative/0.463
5ap7SVEDual specificity protein kinase TTK2.7.12.10.463
3gu7ADPDeath-associated protein kinase 12.7.11.10.461
1jkkANPDeath-associated protein kinase 12.7.11.10.460
2yaaATPDeath-associated protein kinase 2/0.460
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.458
4c3pACPAurora kinase A2.7.11.10.457
3k5uPFQAurora kinase A2.7.11.10.456
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.455
5cvfATPCasein kinase II subunit alpha2.7.11.10.454
5l8lADPAurora kinase A2.7.11.10.453
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.451
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.451
4deeADPAurora kinase A2.7.11.10.449
2j0lANPFocal adhesion kinase 12.7.10.20.448
3c4wATPRhodopsin kinase/0.448
2xrwANPMitogen-activated protein kinase 82.7.11.240.447
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.446
2j0m4STFocal adhesion kinase 12.7.10.20.445
3kvxFMYMitogen-activated protein kinase 102.7.11.240.445
4j95ACPFibroblast growth factor receptor 2/0.445
3t8oATPRhodopsin kinase/0.444
4jbpYPHAurora kinase A2.7.11.10.444
1ig1ANPDeath-associated protein kinase 12.7.11.10.443
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.443
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.443
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.443
5dosATPAurora kinase A2.7.11.10.443
2ebaFADPutative glutaryl-CoA dehydrogenase/0.442
3efwAK8Aurora kinase A2.7.11.10.442
3ortAGSSerine/threonine protein kinase/0.442
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.441
2ojj82AMitogen-activated protein kinase 12.7.11.240.441
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.441
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.441