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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.31.000
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.484
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.475
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.474
3c1y2BADNA integrity scanning protein DisA/0.468
2c0cNAPProstaglandin reductase 310.467
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.466
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.463
2znnS44Peroxisome proliferator-activated receptor alpha/0.463
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
5a3cNADSIR2 family protein/0.460
1fwkADPHomoserine kinase2.7.1.390.459
1nvtNAPShikimate dehydrogenase (NADP(+))/0.459
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.459
4q73FADBifunctional protein PutA/0.459
3gfbNADL-threonine 3-dehydrogenase/0.457
1bv9XV6Gag-Pol polyprotein3.4.23.160.456
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
3idsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.455
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.455
3b70NAPEnoyl reductase LovC10.454
4e2bFMNDehydrogenase/0.454
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.454
4tuvCPZCytochrome P450 1191.140.453
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.452
4uymVOR14-alpha sterol demethylase Cyp51B/0.452
1gqtACPRibokinase/0.451
3kpkFADSulfide-quinone reductase/0.451
3qwbNDPProbable quinone oxidoreductase1.6.5.50.451
3lqfNADGalactitol dehydrogenase/0.450
1bwsNDPGDP-L-fucose synthase/0.449
1tj0FADBifunctional protein PutA1.5.5.20.449
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.449
1mjbACOHistone acetyltransferase ESA1/0.447
3ggoNAIPrephenate dehydrogenase/0.447
4qecNAPElxO/0.447
5a3bAPRSIR2 family protein/0.447
1jipKTN6-deoxyerythronolide B hydroxylase/0.446
2vn0TDZCytochrome P450 2C8/0.446
4q72FADBifunctional protein PutA/0.446
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.445
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.445
4q71FADBifunctional protein PutA/0.445
5c41ACPRibokinase/0.445
5jscFADPutative acyl-CoA dehydrogenase/0.445
1nytNAPShikimate dehydrogenase (NADP(+))/0.444
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.444
2xpuTDCTetracycline repressor protein class D/0.444
3atzFMNProstaglandin F2a synthase/0.443
1w6hTITPlasmepsin-23.4.23.390.442
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.442
5ctsCMCCitrate synthase, mitochondrial2.3.3.10.442
1gcoNADGlucose 1-dehydrogenase1.1.1.470.441
2czfXMPOrotidine 5'-phosphate decarboxylase4.1.1.230.441
2ft9CHDFatty acid-binding protein 2, liver/0.441
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.441
3flwFLWMitogen-activated protein kinase 14/0.441
3gqvNAPEnoyl reductase LovC10.441
1ipeNDPTropinone reductase 21.1.1.2360.440
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.440
2ou2ACOHistone acetyltransferase KAT5/0.440
4yaoFMNNADPH--cytochrome P450 reductase/0.440