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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4eooATPCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4eooATPCyclin-dependent kinase 22.7.11.221.000
4ii5ADPCyclin-dependent kinase 22.7.11.220.592
2cjmATPCyclin-dependent kinase 22.7.11.220.546
1qmzATPCyclin-dependent kinase 22.7.11.220.541
3gu7ADPDeath-associated protein kinase 12.7.11.10.530
4i3zADPCyclin-dependent kinase 22.7.11.220.529
4qnyANPMitogen activated protein kinase, putative/0.519
2cciATPCyclin-dependent kinase 22.7.11.220.510
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.503
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.492
4c3pACPAurora kinase A2.7.11.10.492
5dosATPAurora kinase A2.7.11.10.484
4s33ANPMitogen-activated protein kinase 12.7.11.240.483
3i60E86Mitogen-activated protein kinase 12.7.11.240.478
4fv6E57Mitogen-activated protein kinase 12.7.11.240.478
4btjATPTau-tubulin kinase 12.7.11.10.477
5eg3ACPFibroblast growth factor receptor 2/0.477
5dnrATPAurora kinase A2.7.11.10.476
4deeADPAurora kinase A2.7.11.10.474
1ig1ANPDeath-associated protein kinase 12.7.11.10.473
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.469
3bu5ATPInsulin receptor2.7.10.10.465
3c4wATPRhodopsin kinase/0.463
4xlvACPInsulin receptor2.7.10.10.461
1jkkANPDeath-associated protein kinase 12.7.11.10.460
1jstATPCyclin-dependent kinase 22.7.11.220.460
3lltANPProtein serine/threonine kinase-1/0.458
2w4jADPDeath-associated protein kinase 12.7.11.10.457
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.457
4btjADPTau-tubulin kinase 12.7.11.10.455
4j99ACPFibroblast growth factor receptor 2/0.455
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.454
3c4zADPRhodopsin kinase/0.452
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.452
5ap7SVEDual specificity protein kinase TTK2.7.12.10.450
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.449
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.448
4bbfO19Tyrosine-protein kinase JAK2/0.448
4j95ACPFibroblast growth factor receptor 2/0.448
4ysjADPCalmodulin-like domain protein kinase/0.447
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.446
2j0lANPFocal adhesion kinase 12.7.10.20.444
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.443
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.442