sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ema | BRL | Peroxisome proliferator-activated receptor gamma |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4ema | BRL | Peroxisome proliferator-activated receptor gamma | / | 1.000 | |
| 1zgy | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.656 | |
| 2q8s | L92 | Peroxisome proliferator-activated receptor gamma | / | 0.653 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.649 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.646 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.646 | |
| 2gtk | 208 | Peroxisome proliferator-activated receptor gamma | / | 0.643 | |
| 2zno | S44 | Peroxisome proliferator-activated receptor gamma | / | 0.641 | |
| 1nyx | DRF | Peroxisome proliferator-activated receptor gamma | / | 0.639 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.638 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.636 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.634 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.630 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.622 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.620 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.618 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.616 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.616 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.612 | |
| 4f9m | FCM | Peroxisome proliferator-activated receptor gamma | / | 0.608 | |
| 1k74 | 544 | Peroxisome proliferator-activated receptor gamma | / | 0.604 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.602 | |
| 4hee | 14R | Peroxisome proliferator-activated receptor gamma | / | 0.601 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.599 | |
| 4o8f | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.598 | |
| 2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.595 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.587 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.587 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.586 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.585 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.583 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.582 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.576 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.571 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.561 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.559 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.557 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.557 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.553 | |
| 3gbk | 2PQ | Peroxisome proliferator-activated receptor gamma | / | 0.552 | |
| 4a4w | YFB | Peroxisome proliferator-activated receptor gamma | / | 0.546 | |
| 4a4v | YFD | Peroxisome proliferator-activated receptor gamma | / | 0.540 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.532 | |
| 2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.529 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.528 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.523 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.523 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.494 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.492 | |
| 2rew | REW | Peroxisome proliferator-activated receptor alpha | / | 0.492 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.477 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.471 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.466 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.463 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.463 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.462 | |
| 5ifi | PRX | Acetyl-coenzyme A synthetase | / | 0.462 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.459 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.458 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.456 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.455 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.455 | |
| 3d5f | L41 | Peroxisome proliferator-activated receptor delta | / | 0.454 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 3r7c | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.453 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.453 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.452 | |
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.451 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.451 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.450 | |
| 3nxu | RIT | Cytochrome P450 3A4 | / | 0.450 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.450 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.448 | |
| 1rv1 | IMZ | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.448 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.448 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.447 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.446 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.446 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.446 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.445 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.444 | |
| 3q87 | SAM | N6 ADENINE SPECIFIC DNA METHYLASE (METHYLTRANSFERASE SUPERFAMILY) | / | 0.444 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.444 | |
| 2wq7 | FAD | RE11660p | / | 0.443 | |
| 4l98 | LRG | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.443 | |
| 1al8 | DHP | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.442 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.442 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.442 | |
| 3ieu | GDP | GTPase Era | / | 0.442 | |
| 4ylf | FAD | Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog | / | 0.442 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.441 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1xef | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.441 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3i59 | N6S | CRP-like cAMP-activated global transcriptional regulator | / | 0.441 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.441 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.440 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.440 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.440 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.440 |