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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ceoG0TIntegrase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ceoG0TIntegrase/1.000
4cf8V7HIntegrase/0.757
3zsrO3NIntegrase/0.677
4cezO3NIntegrase/0.677
4ceqQCHIntegrase/0.641
4cerVL4Integrase/0.631
4cesNFWIntegrase/0.603
4ced9NSIntegrase/0.597
4cj3E4FIntegrase/0.596
4cec2SSIntegrase/0.594
4cjuJNSIntegrase/0.588
4cgd8P3Integrase/0.582
4ceaZSWIntegrase/0.581
3zt0ZT0Integrase/0.580
3zsvZSVIntegrase/0.575
4cebZSVIntegrase/0.575
4ceeB0TIntegrase/0.572
4cf23GMIntegrase/0.569
4cfbOM3Integrase/0.569
4cefD0TIntegrase/0.567
4cgiNZLIntegrase/0.567
4cigX0PIntegrase/0.566
4cggK5QIntegrase/0.565
4cgjNZLIntegrase/0.565
4ce9O3NIntegrase/0.562
4cfdS8YIntegrase/0.562
4cghLOZIntegrase/0.561
3zswZSWIntegrase/0.559
3zsqO4NIntegrase/0.558
4cjeQ31Integrase/0.554
4cjrFYMIntegrase/0.553
4cfaWOPIntegrase/0.551
3zsyOM3Integrase/0.548
4cf0O5UIntegrase/0.548
4cjfRVNIntegrase/0.546
4ck1OM1Integrase/0.544
3zt3ZT4Integrase/0.543
4cf1IY7Integrase/0.543
4cjsL0YIntegrase/0.541
4cieY7NIntegrase/0.538
4cifJDXIntegrase/0.535
4cjkH39Integrase/0.533
4chyC5QIntegrase/0.529
3zsxN44Integrase/0.528
4cjqVXOIntegrase/0.528
4cj4S3GIntegrase/0.520
4cjp4D2Integrase/0.520
3zt2ZT2Integrase/0.516
4cfc7NVIntegrase/0.515
4chqCWUIntegrase/0.515
4ck2NVUIntegrase/0.509
4ck3K1TIntegrase/0.504
3zcmPX3Integrase/0.503
3zszOM2Integrase/0.502
3zt1OM1Integrase/0.501
4cj54VWIntegrase/0.499
1powFADPyruvate oxidase1.2.3.30.481
1u4oNDDL-lactate dehydrogenase1.1.1.270.473
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.472
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.469
1di8DTQCyclin-dependent kinase 22.7.11.220.468
1y0s331Peroxisome proliferator-activated receptor delta/0.468
2cchATPCyclin-dependent kinase 22.7.11.220.468
5dp2NAPCurF/0.468
2yxuATPPyridoxal kinase2.7.1.350.465
3vt3VDXVitamin D3 receptor/0.465
4a83DXCMajor pollen allergen Bet v 1-A/0.465
3oibFDAPutative acyl-CoA dehydrogenase/0.464
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.463
5k2bZMAAdenosine receptor A2a/0.463
4ure1PSCyclohexanol dehydrogenase/0.462
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.460
3vrwYS5Vitamin D3 receptor/0.460
4q71FADBifunctional protein PutA/0.459
4xiwAZMCarbonic anhydrase, alpha type/0.459
5h8tRTLRetinol-binding protein 1/0.459
1v9aSAHUncharacterized protein/0.458
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.458
4kip1R9Mitogen-activated protein kinase 14/0.458
3w4yFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.457
4hjoAQ4Epidermal growth factor receptor2.7.10.10.457
3w32W32Epidermal growth factor receptor2.7.10.10.456
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.456
5k2dZMAAdenosine receptor A2a/0.456
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.455
3rj5NADAlcohol dehydrogenase1.1.1.10.455
3w0aDS5Vitamin D3 receptor/0.455
2xw7NDPDihydrofolate reductase/0.454
3a783EVVitamin D3 receptor/0.454
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
4a81DXCMajor pollen allergen Bet v 1-A/0.454
1fm4DXCMajor pollen allergen Bet v 1-L/0.453
1m78NDPDihydrofolate reductase1.5.1.30.453
3k4nFADPyranose 2-oxidase/0.453
4b1iA8PPoly(ADP-ribose) glycohydrolase3.2.1.1430.453
1kqwRTLCellular retinol-binding protein type II/0.452
3w33W19Epidermal growth factor receptor2.7.10.10.452
4x2qNADRetinal dehydrogenase 21.2.1.360.452
5eccNAPDehydrofolate reductase type I/0.452
5iu4ZMAAdenosine receptor A2a/0.452
1ppjANYCytochrome b/0.451
1ur5NADMalate dehydrogenase/0.451
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.451
2vttLZDCyclin-dependent kinase 22.7.11.220.451
1ia1NDPDihydrofolate reductase1.5.1.30.450
2om9AJAPeroxisome proliferator-activated receptor gamma/0.450
3w0yDS4Vitamin D3 receptor/0.450
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.450
1b14NADAlcohol dehydrogenase1.1.1.10.449
1bxsNADRetinal dehydrogenase 11.2.1.360.449
1crbRTLRetinol-binding protein 1/0.449
1xe55FEPlasmepsin-23.4.23.390.449
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.449
4djaFAD(6-4) photolyase/0.449
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
2tpsTPSThiamine-phosphate synthase/0.448
2w3bNDPDihydrofolate reductase1.5.1.30.448
3bv3P39Mitogen-activated protein kinase 14/0.448
3lqfNADGalactitol dehydrogenase/0.448
3p4tFAOPutative acyl-CoA dehydrogenase/0.448
3vjoANPEpidermal growth factor receptor2.7.10.10.448
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.448
5irnADPNucleotide binding oligomerization domain containing 2/0.448
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.447
1u1iNADMyo-inositol-1-phosphate synthase (Ino1)/0.447
2w9hTOPDihydrofolate reductase1.5.1.30.447
3mg3ECHOrange carotenoid-binding protein/0.447
3q44D50M1 family aminopeptidase3.4.110.447
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.447
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.447
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.447
4cgfUJ6Integrase/0.447
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.447
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.447
3bg7FADPyranose 2-oxidase/0.446
3qlrNDPDihydrofolate reductase1.5.1.30.446
3qlsNDPDihydrofolate reductase1.5.1.30.446
4a99FADTetX family tetracycline inactivation enzyme/0.446
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.446
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.445
3gwfFADCyclohexanone monooxygenase/0.445
3jpuTY4Transcriptional activator protein LasR/0.445
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
1b16NAQAlcohol dehydrogenase1.1.1.10.444
1obnASVIsopenicillin N synthase1.21.3.10.444
2vn0TDZCytochrome P450 2C8/0.444
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.444
4bb3KKAIsopenicillin N synthase1.21.3.10.444
4eiyZMAAdenosine receptor A2a/0.444
4em9TCEPeroxisome proliferator-activated receptor gamma/0.444
4nieNBHNuclear receptor ROR-gamma/0.444
4y8wSTRSteroid 21-hydroxylase/0.444
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.444
5k2cZMAAdenosine receptor A2a/0.444
1n83CLRNuclear receptor ROR-alpha/0.443
2bx8AZQSerum albumin/0.443
2igoFADPyranose 2-oxidase/0.443
2pc4ASP_TRP_ASNFructose-bisphosphate aldolase4.1.2.130.443
2v8pADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.443
3il1B5DGlutamate receptor 2/0.443
3pm9FADPutative oxidoreductase/0.443
3poz03PEpidermal growth factor receptor2.7.10.10.443
3rk507ZCyclin-dependent kinase 22.7.11.220.443
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.443
4i6gFADCryptochrome-2/0.443
4kl9NDPDihydrofolate reductase1.5.1.30.443
5e8wSTUTGF-beta receptor type-12.7.11.300.443
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.443
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
1nzfUPGDNA beta-glucosyltransferase/0.442
1tehNADAlcohol dehydrogenase class-31.1.1.10.442
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.442
2fhnBNIAvidin-related protein 4/5/0.442
2hamC33Vitamin D3 receptor/0.442
3unj0BXCyclin-dependent kinase 22.7.11.220.442
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4b4w9L9Bifunctional protein FolD/0.442
4qmySTUSerine/threonine-protein kinase 242.7.11.10.442
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.442
5kf1ACOPredicted acetyltransferase/0.442
1bwsNDPGDP-L-fucose synthase/0.441
1h73ANPHomoserine kinase2.7.1.390.441
1ia3TQ5Dihydrofolate reductase1.5.1.30.441
1osvCHCBile acid receptor/0.441
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
2c29NAPDihydroflavonol 4-reductase/0.441
2wxvWXVCyclin-dependent kinase 22.7.11.220.441
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.441
3ggfGVDSerine/threonine-protein kinase 26/0.441
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.441
3vt5YI2Vitamin D3 receptor/0.441
3w0jT08Vitamin D3 receptor/0.441
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.441
4lva20MNicotinamide phosphoribosyltransferase2.4.2.120.441
4qmpDKISerine/threonine-protein kinase 242.7.11.10.441
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.441
5iubCLRAdenosine receptor A2a/0.441
5iu86DZAdenosine receptor A2a/0.441
1j49NADD-lactate dehydrogenase1.1.1.280.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.440
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.440
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
3pxyJWSCyclin-dependent kinase 22.7.11.220.440
3q43D66M1 family aminopeptidase3.4.110.440
3r7iX9ICyclin-dependent kinase 22.7.11.220.440
3w0gW07Vitamin D3 receptor/0.440
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.440
4hxyNDPPlm1/0.440
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.440