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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3zh8C58Protein kinase C iota type2.7.11.13

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3zh8C58Protein kinase C iota type2.7.11.131.000
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.484
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.483
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.481
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.480
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.478
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.477
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.477
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.477
1zrzBI1Protein kinase C iota type2.7.11.130.475
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.475
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.469
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.469
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.468
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.466
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.464
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.464
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.463
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.463
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.462
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.460
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.459
2in6839Wee1-like protein kinase2.7.10.20.458
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.458
1aq1STUCyclin-dependent kinase 22.7.11.220.456
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.456
2vd5BI8Myotonin-protein kinase2.7.11.10.456
4ez50RSCyclin-dependent kinase 62.7.11.220.456
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.455
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.455
1eh4IC1Casein kinase I homolog 12.7.11.10.454
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
4ji91M3Tyrosine-protein kinase JAK2/0.454
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.453
4fv6E57Mitogen-activated protein kinase 12.7.11.240.453
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.453
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.452
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.452
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.452
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.451
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.451
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.451
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.451
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.451
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.450
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.450
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.450
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.448
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.448
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.447
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.447
3zewSTUEphrin type-B receptor 42.7.10.10.447
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.447
4qmpDKISerine/threonine-protein kinase 242.7.11.10.447
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.446
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.445
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.445
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.444
3gu83GUDeath-associated protein kinase 12.7.11.10.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
1g5sI17Cyclin-dependent kinase 22.7.11.220.443
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.443
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.442
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.442
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.441
3at4CCKCasein kinase II subunit alpha2.7.11.10.441
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.441
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
3be9P04Casein kinase II subunit alpha2.7.11.10.440
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.440
3gubGUBDeath-associated protein kinase 12.7.11.10.440
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.440
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.440
4y95746Tyrosine-protein kinase/0.440