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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3w2o03PEpidermal growth factor receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3w2o03PEpidermal growth factor receptor2.7.10.11.000
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.531
2vrx447Aurora kinase B-A2.7.11.10.517
4aotGW8Serine/threonine-protein kinase 102.7.11.10.511
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.487
2c7xNRBCytochrome P450 monooxygenase PikC/0.486
2j7t274Serine/threonine-protein kinase 102.7.11.10.486
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.486
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.486
3begANPSRSF protein kinase 12.7.11.10.485
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.483
4joa3DKALK tyrosine kinase receptor2.7.10.10.482
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.477
2c6eHPMAurora kinase A2.7.11.10.476
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.476
3ictCOACoenzyme A disulfide reductase/0.476
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.475
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.473
4gt3ATPMitogen-activated protein kinase 12.7.11.240.473
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.470
1mqbANPEphrin type-A receptor 22.7.10.10.469
3icsCOACoenzyme A disulfide reductase/0.468
3zewSTUEphrin type-B receptor 42.7.10.10.468
4ansVGHALK tyrosine kinase receptor2.7.10.10.466
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.463
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.463
4b7dQLECytochrome P450 monooxygenase PikC/0.460
4c3pACPAurora kinase A2.7.11.10.460
4anqVGHALK tyrosine kinase receptor2.7.10.10.458
3w2sW2REpidermal growth factor receptor2.7.10.10.457
4btjATPTau-tubulin kinase 12.7.11.10.456
1fm4DXCMajor pollen allergen Bet v 1-L/0.454
4nka2K7Fibroblast growth factor receptor 1/0.454
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.453
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.452
3zk5Z18Cytochrome P450 monooxygenase PikC/0.452
4id71G0Activated CDC42 kinase 1/0.452
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.452
1k6pXN3Gag-Pol polyprotein3.4.23.160.451
4jboWPHAurora kinase A2.7.11.10.451
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.450
2j0m4STFocal adhesion kinase 12.7.10.20.449
4qo9627Serine/threonine-protein kinase 242.7.11.10.449
2yfxVGHALK tyrosine kinase receptor2.7.10.10.448
3w2rW2REpidermal growth factor receptor2.7.10.10.448
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.448
2c6hPXICytochrome P450 monooxygenase PikC/0.447
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.447
1bygSTUTyrosine-protein kinase CSK/0.445
2ijmADPFocal adhesion kinase 12.7.10.20.445
2qo7ANPEphrin type-A receptor 32.7.10.10.445
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.444
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.444
3hx4ANPCalmodulin-domain protein kinase 1/0.444
3uvqFS8Mitogen-activated protein kinase 14/0.444
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.443
2c3qGTXGlutathione S-transferase theta-12.5.1.180.443
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.443
2itvANPEpidermal growth factor receptor2.7.10.10.442
3bc3OPTCathepsin L13.4.22.150.442
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.442
3mpaSB2Mitogen-activated protein kinase 14/0.441
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.441
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.441
4gk4L90Ephrin type-A receptor 32.7.10.10.441
4jbpYPHAurora kinase A2.7.11.10.441
4qmlANPSerine/threonine-protein kinase 242.7.11.10.441
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.441
4aguD15Cyclin-dependent kinase-like 1/0.440