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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3uxyNADShort-chain dehydrogenase/reductase SDR

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3uxyNADShort-chain dehydrogenase/reductase SDR/1.000
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.558
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.539
3rj5NADAlcohol dehydrogenase1.1.1.10.527
5jlaNADPutative short-chain dehydrogenase/reductase/0.526
2wdzNADGalactitol dehydrogenase/0.523
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.523
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.521
5lc1NADL-threonine 3-dehydrogenase/0.517
4gh5NADShort-chain dehydrogenase/reductase SDR/0.516
1b15NAEAlcohol dehydrogenase1.1.1.10.514
3ak4NADNADH-dependent quinuclidinone reductase/0.514
3rj9NADAlcohol dehydrogenase1.1.1.10.513
2wsbNADGalactitol dehydrogenase/0.511
1sbyNADAlcohol dehydrogenase1.1.1.10.509
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.505
3wdsNADNADH-dependent quinuclidinone reductase/0.504
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.503
1pr9NAPL-xylulose reductase1.1.1.100.501
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.501
1mg5NAIAlcohol dehydrogenase1.1.1.10.500
1iy8NADLevodione reductase/0.499
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.499
3qrwNDPPutative ketoacyl reductase1.3.10.497
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.496
4fn4NADShort chain dehydrogenase/0.494
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.493
3a1nNADNDP-sugar epimerase/0.491
4dc1NDPPutative ketoacyl reductase1.3.10.491
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.491
1b16NAQAlcohol dehydrogenase1.1.1.10.489
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.489
1w4zNAPPutative ketoacyl reductase1.3.10.489
1zemNADXylitol dehydrogenase/0.489
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.489
2dteNAIGlucose 1-dehydrogenase related protein/0.488
4nbwNADShort-chain dehydrogenase/reductase SDR/0.488
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.487
1b14NADAlcohol dehydrogenase1.1.1.10.486
3a4vNADNDP-sugar epimerase/0.486
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.485
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.485
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.484
3gy0NAPNAD(P)-dependent oxidoreductase/0.482
4hwkNAPSepiapterin reductase1.1.1.1530.481
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.480
1x7hNDPPutative ketoacyl reductase1.3.10.476
1ae1NAPTropinone reductase 1/0.474
1wntNAPL-xylulose reductase1.1.1.100.474
2yy7NADL-threonine dehydrogenase/0.472
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.472
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.471
3lqfNADGalactitol dehydrogenase/0.471
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.471
4j7xNAPSepiapterin reductase1.1.1.1530.471
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.470
3p19NDPPutative blue fluorescent protein/0.470
3sx2NADUncharacterized protein/0.470
3f1kNAPUncharacterized oxidoreductase YciK10.468
3sjuNDPKeto reductase/0.468
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.467
1snyNAPLD36273p/0.465
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.465
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.464
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.462
4yaiNAIC alpha-dehydrogenase/0.462
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.460
1ipeNDPTropinone reductase 21.1.1.2360.460
1x7gNAPPutative ketoacyl reductase1.3.10.459
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.458
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.458
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.457
2p5uNADUDP-glucose 4-epimerase/0.457
3d3wNAPL-xylulose reductase1.1.1.100.457
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.457
3toxNAPPutative oxidoreductase/0.457
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.456
3wmxNADNAD dependent epimerase/dehydratase/0.456
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.456
4j7uNAPSepiapterin reductase1.1.1.1530.456
1oaaNAPSepiapterin reductase1.1.1.1530.455
1xg5NAPDehydrogenase/reductase SDR family member 11/0.452
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
3s55NADPutative short-chain dehydrogenase/reductase/0.450
4qecNAPElxO/0.450
2yutNAPPutative short-chain oxidoreductase/0.449
1xkqNDPUncharacterized protein/0.448
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.448
2bd0NAPSepiapterin reductase/0.447
3ggoNAIPrephenate dehydrogenase/0.447
3w8dNAD3-hydroxybutyrate dehydrogenase/0.447
1g6kNADGlucose 1-dehydrogenase1.1.1.470.446
4idgNADPutative UDP-glucose 4-epimerase/0.446
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.446
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.445
1z7eATPBifunctional polymyxin resistance protein ArnA/0.444
3w8eNAD3-hydroxybutyrate dehydrogenase/0.442
4qedNAPElxO/0.442
4yagNAIC alpha-dehydrogenase/0.442
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.441
3w8fNAD3-hydroxybutyrate dehydrogenase/0.441
4bmvNAPShort-chain dehydrogenase/0.441
1geeNADGlucose 1-dehydrogenase1.1.1.470.440