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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3rnnRNNGlutamate receptor 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3rnnRNNGlutamate receptor 2/1.000
3bbrBHYGlutamate receptor 2/0.574
2xx91NFGlutamate receptor 2/0.569
2xhd7T9Glutamate receptor 2/0.523
3kgcLY7Glutamate receptor 2/0.523
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.501
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.482
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.481
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.479
2dteNAIGlucose 1-dehydrogenase related protein/0.478
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.476
4gh5NADShort-chain dehydrogenase/reductase SDR/0.476
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.474
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.467
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.465
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.464
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.464
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.464
2givACOHistone acetyltransferase KAT8/0.463
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.463
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.462
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.461
4udrFAD5-(hydroxymethyl)furfural oxidase/0.461
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
2y05NAPProstaglandin reductase 1/0.460
4uyf73BBromodomain-containing protein 2/0.460
1ae1NAPTropinone reductase 1/0.459
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1kkq471Peroxisome proliferator-activated receptor alpha/0.458
1n7hNDPGDP-mannose 4,6 dehydratase 24.2.1.470.458
4jlk1NODeoxycytidine kinase2.7.1.740.458
4mihFADPyranose 2-oxidase1.1.3.100.458
4n9iPCGCatabolite expression activator/0.458
5jlaNADPutative short-chain dehydrogenase/reductase/0.458
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.457
4tuvCPZCytochrome P450 1191.140.457
3t3c017Gag-Pol polyprotein3.4.23.160.456
5jscFADPutative acyl-CoA dehydrogenase/0.456
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.455
4rvgTYDD-mycarose 3-C-methyltransferase/0.454
1zemNADXylitol dehydrogenase/0.453
2vhxNADAlanine dehydrogenase1.4.1.10.453
3il1B5DGlutamate receptor 2/0.453
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.453
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.452
4dh60KNBeta-secretase 13.4.23.460.452
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.451
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.451
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.451
4ia3BIVVitamin D3 receptor A/0.451
1e3eNAIAlcohol dehydrogenase 41.1.1.10.450
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.450
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.450
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.450
1bw9NADPhenylalanine dehydrogenase/0.449
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.449
4irnFADAnaB/0.449
1xe55FEPlasmepsin-23.4.23.390.448
2q4bNAPUncharacterized protein At5g02240/0.448
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.447
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.447
1lf3EH5Plasmepsin-23.4.23.390.446
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.446
1mj9COAHistone acetyltransferase ESA1/0.445
1tehNADAlcohol dehydrogenase class-31.1.1.10.445
2ebaFADPutative glutaryl-CoA dehydrogenase/0.445
3syiFADSulfide-quinone reductase/0.445
4ambDUDPutative glycosyl transferase/0.445
4fn4NADShort chain dehydrogenase/0.445
4g1z0VPVitamin D3 receptor A/0.445
3qlsNDPDihydrofolate reductase1.5.1.30.444
1fy7COAHistone acetyltransferase ESA1/0.443
1qiqACCIsopenicillin N synthase1.21.3.10.443
1wntNAPL-xylulose reductase1.1.1.100.443
1x7dNADPutative ornithine cyclodeaminase/0.443
3b70NAPEnoyl reductase LovC10.443
3uxyNADShort-chain dehydrogenase/reductase SDR/0.443
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.443
4wjiNAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase/0.443
1x7hNDPPutative ketoacyl reductase1.3.10.442
3qrwNDPPutative ketoacyl reductase1.3.10.442
1lluNADAlcohol dehydrogenase/0.441
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3t2zFADSulfide-quinone reductase/0.441
4iv6FDAIsovaleryl-CoA dehydrogenase/0.441
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2jb4A14Isopenicillin N synthase1.21.3.10.440
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
4q73FADBifunctional protein PutA/0.440
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440