scPDB - Distribution of Binding site Similarity values of 3m64 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3m64	393	Aldose reductase	1.1.1.21

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3m64	393	Aldose reductase	1.1.1.21	1.000
2ikj	393	Aldose reductase	1.1.1.21	0.801
2dv0	ZST	Aldose reductase	1.1.1.21	0.737
3lql	LDT	Aldose reductase	1.1.1.21	0.736
2fz9	ZST	Aldose reductase	1.1.1.21	0.724
3lbo	LDT	Aldose reductase	1.1.1.21	0.704
2hvo	ZST	Aldose reductase	1.1.1.21	0.689
3m4h	388	Aldose reductase	1.1.1.21	0.684
2hv5	ZST	Aldose reductase	1.1.1.21	0.668
2pdm	ZST	Aldose reductase	1.1.1.21	0.660
3lz5	LDT	Aldose reductase	1.1.1.21	0.660
2pdx	ZST	Aldose reductase	1.1.1.21	0.657
4gca	2X9	Aldose reductase	1.1.1.21	0.655
2ikh	LIT	Aldose reductase	1.1.1.21	0.653
2hvn	ZST	Aldose reductase	1.1.1.21	0.650
3ghr	LDT	Aldose reductase	1.1.1.21	0.643
1z89	62P	Aldose reductase	1.1.1.21	0.642
1t41	ID5	Aldose reductase	1.1.1.21	0.639
2fz8	ZST	Aldose reductase	1.1.1.21	0.635
2pdi	ZST	Aldose reductase	1.1.1.21	0.631
3ld5	LDT	Aldose reductase	1.1.1.21	0.626
1z3n	3NA	Aldose reductase	1.1.1.21	0.623
2iki	388	Aldose reductase	1.1.1.21	0.617
3mb9	ZST	Aldose reductase	1.1.1.21	0.617
3mc5	393	Aldose reductase	1.1.1.21	0.609
1t40	ID5	Aldose reductase	1.1.1.21	0.608
3ghs	LDT	Aldose reductase	1.1.1.21	0.607
3m0i	ZST	Aldose reductase	1.1.1.21	0.604
2pd5	ZST	Aldose reductase	1.1.1.21	0.603
2pdb	ZST	Aldose reductase	1.1.1.21	0.603
2pdg	47D	Aldose reductase	1.1.1.21	0.603
2pdl	TOL	Aldose reductase	1.1.1.21	0.599
2pdc	393	Aldose reductase	1.1.1.21	0.593
2pdf	ZST	Aldose reductase	1.1.1.21	0.587
2dux	ZST	Aldose reductase	1.1.1.21	0.585
2pdh	47D	Aldose reductase	1.1.1.21	0.581
3len	ZST	Aldose reductase	1.1.1.21	0.581
3t42	3T4	Aldose reductase	1.1.1.21	0.580
1pwl	BFI	Aldose reductase	1.1.1.21	0.579
4yu1	53N	Aldose reductase	1.1.1.21	0.578
2pdu	393	Aldose reductase	1.1.1.21	0.577
2pzn	393	Aldose reductase	1.1.1.21	0.576
1iei	ZES	Aldose reductase	1.1.1.21	0.568
3ght	LDT	Aldose reductase	1.1.1.21	0.567
3ghu	LDT	Aldose reductase	1.1.1.21	0.561
2pdn	47D	Aldose reductase	1.1.1.21	0.560
2pdp	393	Aldose reductase	1.1.1.21	0.557
2duz	ZST	Aldose reductase	1.1.1.21	0.556
2fzd	TOL	Aldose reductase	1.1.1.21	0.554
2i16	LDT	Aldose reductase	1.1.1.21	0.552
2i17	LDT	Aldose reductase	1.1.1.21	0.548
1el3	I84	Aldose reductase	1.1.1.21	0.540
1frb	ZST	Aldose reductase-related protein 2	/	0.540
2pdj	393	Aldose reductase	1.1.1.21	0.539
1us0	LDT	Aldose reductase	1.1.1.21	0.526
2fzb	TOL	Aldose reductase	1.1.1.21	0.520
3g5e	Q74	Aldose reductase	1.1.1.21	0.519
2pdq	47D	Aldose reductase	1.1.1.21	0.516
1zua	TOL	Aldo-keto reductase family 1 member B10	1.1.1	0.515
2inz	OHP	Aldose reductase	1.1.1.21	0.515
1ah3	TOL	Aldose reductase	1.1.1.21	0.508
2iqd	LPA	Aldose reductase	1.1.1.21	0.504
3g4k	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.494
2pdw	FID	Aldose reductase	1.1.1.21	0.492
5liu	388	Aldo-keto reductase family 1 member B10	1.1.1	0.478
2qxw	LDT	Aldose reductase	1.1.1.21	0.476
2f38	15M	Aldo-keto reductase family 1 member C3	/	0.473
1q9m	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.472
2f2k	TGG	Aldose reductase	1.1.1.21	0.471
2pdy	FID	Aldose reductase	1.1.1.21	0.469
3g49	3G4	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.468
1u65	CP0	Acetylcholinesterase	3.1.1.7	0.466
2agt	FID	Aldose reductase	1.1.1.21	0.463
2qim	ZEA	Class 10 plant pathogenesis-related protein	/	0.463
3g4i	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.462
4jq4	IMN	Aldo-keto reductase family 1 member C2	/	0.461
1oyn	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.460
4i9i	1DY	Tankyrase-1	2.4.2.30	0.460
4li6	1XO	Tankyrase-1	2.4.2.30	0.460
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.458
3s3g	TLT	Aldose reductase	1.1.1.21	0.458
1ef3	FID	Aldose reductase	1.1.1.21	0.457
3pn1	IVH	DNA ligase	/	0.457
1aqu	EST	Estrogen sulfotransferase, testis isoform	2.8.2.4	0.456
2xup	TZ5	Acetylcholinesterase	3.1.1.7	0.455
3f3y	4OA	Bile salt sulfotransferase	2.8.2.14	0.455
4hyf	1AK	Tankyrase-2	2.4.2.30	0.455
3u2c	SUZ	Aldose reductase	1.1.1.21	0.454
4xwt	U5P	Ribonuclease J	/	0.454
1zgc	A2E	Acetylcholinesterase	3.1.1.7	0.453
2fm0	M98	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.453
2oaz	I96	Methionine aminopeptidase 2	/	0.453
1eko	I84	Aldose reductase	1.1.1.21	0.452
1obn	ASV	Isopenicillin N synthase	1.21.3.1	0.452
3k4s	0MO	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.452
1xor	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.451
2pdk	SBI	Aldose reductase	1.1.1.21	0.451
3gf4	UPG	UDP-galactopyranose mutase	5.4.99.9	0.451
1p91	SAM	23S rRNA (guanine(745)-N(1))-methyltransferase	/	0.450
3g58	988	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.450
3uzz	TES	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.450
2aov	C2M	Histamine N-methyltransferase	2.1.1.8	0.449
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.449
1q83	TZ5	Acetylcholinesterase	3.1.1.7	0.448
1xoq	ROF	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.448
3q9b	B3N	Acetylpolyamine amidohydrolase	/	0.448
4wev	SUZ	Aldo-keto reductase family 1 member B10	1.1.1	0.448
5d5a	CAU	Beta-2 adrenergic receptor	/	0.448
2aot	2PM	Histamine N-methyltransferase	2.1.1.8	0.447
2cek	N8T	Acetylcholinesterase	3.1.1.7	0.447
3zku	HCV	Isopenicillin N synthase	1.21.3.1	0.447
4e0u	0MV	Cyclic dipeptide N-prenyltransferase	/	0.447
2w6c	BM4	Acetylcholinesterase	3.1.1.7	0.445
3dyl	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.445
4bfx	ZVX	Pantothenate kinase	2.7.1.33	0.445
1tco	FK5	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.444
1tco	FK5	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	3.1.3.16	0.444
2bjs	ACV	Isopenicillin N synthase	1.21.3.1	0.444
4msk	2C8	Tankyrase-1	2.4.2.30	0.444
1upw	444	Oxysterols receptor LXR-beta	/	0.443
1w4l	GL8	Acetylcholinesterase	3.1.1.7	0.443
3aiv	HBO	4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic	3.2.1.182	0.443
3jsi	WTC	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.443
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.443
4b13	X25	Glycylpeptide N-tetradecanoyltransferase	/	0.443
1ry8	RUT	Aldo-keto reductase family 1 member C3	/	0.442
3jsx	CC2	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.442
4psb	GA3	Cytokinin-specific binding protein	/	0.442
1pqc	444	Oxysterols receptor LXR-beta	/	0.441
1xl8	152	Peroxisomal carnitine O-octanoyltransferase	2.3.1.137	0.441
2v0m	KLN	Cytochrome P450 3A4	/	0.441
2vqq	TFG	Histone deacetylase 4	3.5.1.98	0.441
4mt9	2D6	Tankyrase-1	2.4.2.30	0.441
1c7o	PPG	Hemolysin	/	0.440
1y2b	DEE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.440
3uzx	AOX	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.440
4dbs	0HV	Aldo-keto reductase family 1 member C3	/	0.440
4pab	THG	Dimethylglycine dehydrogenase, mitochondrial	1.5.8.4	0.440
5fd8	A5A	Putative carboxypeptidase yocD	/	0.440