Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lfeZ84Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3lfeZ84Mitogen-activated protein kinase 14/1.000
3hv3R49Mitogen-activated protein kinase 14/0.553
3l8sBFFMitogen-activated protein kinase 14/0.540
2bakAQZMitogen-activated protein kinase 14/0.530
4a9yAQZMitogen-activated protein kinase 14/0.530
2ewaSB2Mitogen-activated protein kinase 14/0.519
3gcq1BUMitogen-activated protein kinase 14/0.507
3gc9B45Mitogen-activated protein kinase 112.7.11.240.489
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.489
3iw8HIZMitogen-activated protein kinase 14/0.487
2og81N8Tyrosine-protein kinase Lck2.7.10.20.483
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.480
3hub469Mitogen-activated protein kinase 14/0.479
2ejzSAHDiphthine synthase/0.475
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.475
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.472
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.471
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.470
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.466
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.465
3uvqFS8Mitogen-activated protein kinase 14/0.463
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.463
1ouy094Mitogen-activated protein kinase 14/0.462
1q5dEPBEpothilone C/D epoxidase1.140.461
2zb1GK4Mitogen-activated protein kinase 14/0.461
3ds6A17Mitogen-activated protein kinase 14/0.460
4r20AERCytochrome P450 family 17 polypeptide 2/0.460
1pkfEPDEpothilone C/D epoxidase1.140.459
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
1blzACVIsopenicillin N synthase1.21.3.10.458
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.457
1qiqACCIsopenicillin N synthase1.21.3.10.456
4jbtASDCytochrome P450 monooxygenase/0.456
1hfqMOTDihydrofolate reductase1.5.1.30.455
3lfcZ86Mitogen-activated protein kinase 14/0.454
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.454
5bp9SAHPutative methyltransferase protein/0.454
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.453
4kfj1R0Dihydrofolate reductase1.5.1.30.453
2oscMUHAngiopoietin-1 receptor2.7.10.10.452
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.452
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
2p4iMR9Angiopoietin-1 receptor2.7.10.10.451
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.451
2gfsPQBMitogen-activated protein kinase 14/0.450
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4equG6ISerine/threonine-protein kinase 102.7.11.10.450
4jlj1NMDeoxycytidine kinase2.7.1.740.450
3uzaT4GAdenosine receptor A2a/0.450
1pqc444Oxysterols receptor LXR-beta/0.449
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.447
3p99LNPLanosterol 14-alpha-demethylase/0.447
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.447
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.446
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.446
1uzwCDHIsopenicillin N synthase1.21.3.10.445
3uibSB2Putative mitogen-activated protein kinase/0.445
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.445
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.445
1bk0ACVIsopenicillin N synthase1.21.3.10.444
1c7oPPGHemolysin/0.444
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.444
4b4w9L9Bifunctional protein FolD/0.444
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3l6jZ90Alr2278 protein/0.443
3pg3DG7Mitogen-activated protein kinase 14/0.443
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.443
1obnASVIsopenicillin N synthase1.21.3.10.442
4rh10TTSpore photoproduct lyase/0.442
4twnB96Ephrin type-A receptor 32.7.10.10.442
2pl0STITyrosine-protein kinase Lck2.7.10.20.441
3itzP66Mitogen-activated protein kinase 14/0.441
3zoiM2WIsopenicillin N synthase1.21.3.10.441
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.440
3qm4PN0Cytochrome P450 2D6/0.440
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.440