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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lenZSTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3lenZSTAldose reductase1.1.1.211.000
3mb9ZSTAldose reductase1.1.1.210.697
2pd5ZSTAldose reductase1.1.1.210.639
2pdbZSTAldose reductase1.1.1.210.635
3mc5393Aldose reductase1.1.1.210.629
3m0iZSTAldose reductase1.1.1.210.628
2pdmZSTAldose reductase1.1.1.210.625
2pdp393Aldose reductase1.1.1.210.621
2hvoZSTAldose reductase1.1.1.210.618
4gca2X9Aldose reductase1.1.1.210.615
2hvnZSTAldose reductase1.1.1.210.608
2fz9ZSTAldose reductase1.1.1.210.607
2fz8ZSTAldose reductase1.1.1.210.600
2hv5ZSTAldose reductase1.1.1.210.599
2duzZSTAldose reductase1.1.1.210.596
3t423T4Aldose reductase1.1.1.210.596
1z3n3NAAldose reductase1.1.1.210.595
2pdxZSTAldose reductase1.1.1.210.593
2dv0ZSTAldose reductase1.1.1.210.590
1t40ID5Aldose reductase1.1.1.210.587
2duxZSTAldose reductase1.1.1.210.586
2iki388Aldose reductase1.1.1.210.583
3lboLDTAldose reductase1.1.1.210.582
1t41ID5Aldose reductase1.1.1.210.581
2pdc393Aldose reductase1.1.1.210.581
3m64393Aldose reductase1.1.1.210.577
1frbZSTAldose reductase-related protein 2/0.576
2qxwLDTAldose reductase1.1.1.210.576
2pdh47DAldose reductase1.1.1.210.575
2pdiZSTAldose reductase1.1.1.210.571
2ikj393Aldose reductase1.1.1.210.570
2pdg47DAldose reductase1.1.1.210.570
1z8962PAldose reductase1.1.1.210.567
4yu153NAldose reductase1.1.1.210.567
3lqlLDTAldose reductase1.1.1.210.566
3m4h388Aldose reductase1.1.1.210.565
2i16LDTAldose reductase1.1.1.210.562
3g5eQ74Aldose reductase1.1.1.210.562
2pzn393Aldose reductase1.1.1.210.560
2pdfZSTAldose reductase1.1.1.210.559
3ghsLDTAldose reductase1.1.1.210.559
1us0LDTAldose reductase1.1.1.210.557
3ld5LDTAldose reductase1.1.1.210.556
3ghuLDTAldose reductase1.1.1.210.555
3ghtLDTAldose reductase1.1.1.210.552
2ikhLITAldose reductase1.1.1.210.551
2pdlTOLAldose reductase1.1.1.210.551
1pwlBFIAldose reductase1.1.1.210.550
3lz5LDTAldose reductase1.1.1.210.549
2pdn47DAldose reductase1.1.1.210.548
1ieiZESAldose reductase1.1.1.210.543
2i17LDTAldose reductase1.1.1.210.542
3ghrLDTAldose reductase1.1.1.210.541
2fzdTOLAldose reductase1.1.1.210.518
1ah3TOLAldose reductase1.1.1.210.505
2pdu393Aldose reductase1.1.1.210.504
1zuaTOLAldo-keto reductase family 1 member B101.1.10.503
2pdq47DAldose reductase1.1.1.210.500
2pdj393Aldose reductase1.1.1.210.498
3b82NADExotoxin A2.4.2.360.485
1ry8RUTAldo-keto reductase family 1 member C3/0.479
2v0mKLNCytochrome P450 3A4/0.464
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.464
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.464
4msk2C8Tankyrase-12.4.2.300.463
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.462
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.462
5d5aCAUBeta-2 adrenergic receptor/0.462
3f3y4OABile salt sulfotransferase2.8.2.140.461
4wevSUZAldo-keto reductase family 1 member B101.1.10.461
2xuhTZ4Acetylcholinesterase3.1.1.70.460
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.459
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.456
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.456
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.456
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.456
2f3815MAldo-keto reductase family 1 member C3/0.455
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
5liu388Aldo-keto reductase family 1 member B101.1.10.455
4li61XOTankyrase-12.4.2.300.454
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2fzbTOLAldose reductase1.1.1.210.451
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.451
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.451
2xuoTZ4Acetylcholinesterase3.1.1.70.450
4kmzFOLFolate receptor beta/0.450
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.449
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.449
3sn6P0GBeta-2 adrenergic receptor/0.449
2xuqTZ4Acetylcholinesterase3.1.1.70.448
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
4dbs0HVAldo-keto reductase family 1 member C3/0.448
4tkg09LTankyrase-22.4.2.300.448
2cbqTH2Neocarzinostatin/0.447
1rpwDIDHTH-type transcriptional regulator QacR/0.446
2xujTZ5Acetylcholinesterase3.1.1.70.446
4fam0SZAldo-keto reductase family 1 member C3/0.446
4j7hTRHPCZA361.3/0.446
1ry0PG2Aldo-keto reductase family 1 member C3/0.445
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.445
1dgbNDPCatalase1.11.1.60.444
2xukTZ5Acetylcholinesterase3.1.1.70.444
3akn11DFatty acid-binding protein, intestinal/0.444
3q9bB3NAcetylpolyamine amidohydrolase/0.444
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.444
5d6lCAUBeta-2 adrenergic receptor/0.444
1hqtNAPAlcohol dehydrogenase [NADP(+)]1.1.1.20.443
1o6qR17Squalene--hopene cyclase4.2.1.1290.443
2bfmTOPPteridine reductase 11.5.1.330.443
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.443
1zgcA2EAcetylcholinesterase3.1.1.70.442
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.442
3ghvGHCDihydrofolate reductase1.5.1.30.442
3u9y09LTankyrase-22.4.2.300.442
3vf60H6Glucokinase2.7.1.20.442
4e2zJHZMethyltransferase/0.442
3nyaJTZBeta-2 adrenergic receptor/0.442
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.441
4hmn16JAldo-keto reductase family 1 member C3/0.441
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.440
1h22E10Acetylcholinesterase3.1.1.70.440
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.440
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.440
8catNDPCatalase1.11.1.60.440