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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.58

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.581.000
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.757
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.706
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.659
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.653
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.646
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.637
1s63778Protein farnesyltransferase subunit beta2.5.1.580.636
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.634
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.634
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.627
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.624
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.615
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.573
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.573
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.573
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.566
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.562
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.550
3sfy3FYUncharacterized protein/0.546
3q7fED2Uncharacterized protein/0.541
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.501
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.498
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.493
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.490
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.485
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.483
3kslSZHProtein farnesyltransferase subunit beta2.5.1.580.475
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.472
4lnbED5CaaX farnesyltransferase beta subunit Ram1/0.470
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.580.468
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.467
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.463
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.463
1n4qLYS_CYS_VAL_ILE_LEUGeranylgeranyl transferase type-1 subunit beta2.5.1.590.457
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.450
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.445