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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3i60E86Mitogen-activated protein kinase 12.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3i60E86Mitogen-activated protein kinase 12.7.11.241.000
4fv6E57Mitogen-activated protein kinase 12.7.11.240.620
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.582
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.580
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.544
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.507
4qnyANPMitogen activated protein kinase, putative/0.505
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.500
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.489
1qmzATPCyclin-dependent kinase 22.7.11.220.488
4btjATPTau-tubulin kinase 12.7.11.10.488
5dnrATPAurora kinase A2.7.11.10.487
5dosATPAurora kinase A2.7.11.10.484
4btjADPTau-tubulin kinase 12.7.11.10.482
2yaaATPDeath-associated protein kinase 2/0.481
4eooATPCyclin-dependent kinase 22.7.11.220.480
2vu3LZECyclin-dependent kinase 22.7.11.220.478
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.476
4gt3ATPMitogen-activated protein kinase 12.7.11.240.475
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.473
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.472
2ojj82AMitogen-activated protein kinase 12.7.11.240.471
5e8ySTUTGF-beta receptor type-22.7.11.300.471
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.466
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.465
3lltANPProtein serine/threonine kinase-1/0.464
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.463
4h3qANPMitogen-activated protein kinase 12.7.11.240.463
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.461
4aguD15Cyclin-dependent kinase-like 1/0.460
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.460
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.459
3gu7ADPDeath-associated protein kinase 12.7.11.10.457
4ii5ADPCyclin-dependent kinase 22.7.11.220.456
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.455
2j0m4STFocal adhesion kinase 12.7.10.20.455
3kvxFMYMitogen-activated protein kinase 102.7.11.240.455
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.454
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.454
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.454
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.453
3s1h56ZCyclin-dependent kinase 22.7.11.220.452
3t8oATPRhodopsin kinase/0.452
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.452
4deeADPAurora kinase A2.7.11.10.452
4s33ANPMitogen-activated protein kinase 12.7.11.240.451
4c3pACPAurora kinase A2.7.11.10.450
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.450
2uzbC75Cyclin-dependent kinase 22.7.11.220.449
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3c4xATPRhodopsin kinase/0.449
3rak03ZCyclin-dependent kinase 22.7.11.220.449
4aqc88ATyrosine-protein kinase JAK2/0.449
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.448
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.447
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4j95ACPFibroblast growth factor receptor 2/0.447
4jbpYPHAurora kinase A2.7.11.10.447
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.445
5ap7SVEDual specificity protein kinase TTK2.7.12.10.445
5av2KMPDeath-associated protein kinase 12.7.11.10.445
3c4zADPRhodopsin kinase/0.444
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.444
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.443
4j99ACPFibroblast growth factor receptor 2/0.443
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.443
1bygSTUTyrosine-protein kinase CSK/0.442
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.442
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.441
4l9i8PRRhodopsin kinase/0.441
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.440
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.440