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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3h2cB58Dihydropteroate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3h2cB58Dihydropteroate synthase/1.000
3tydXHPDihydropteroate synthase/0.564
3h24B55Dihydropteroate synthase/0.544
3h2nB62Dihydropteroate synthase/0.515
3tycXHPDihydropteroate synthase/0.515
2dzbHH2Dihydropteroate synthase/0.503
1twwHH2Dihydropteroate synthase/0.501
4u0oMTALipoyl synthase 2/0.465
4k81GTPGTPase HRas/0.449
4m55NADUDP-glucuronic acid decarboxylase 14.1.1.350.447
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.446
1aj22PHDihydropteroate synthase/0.443
2bmbPMMFolic acid synthesis protein FOL1/0.443
3cr7PPSAdenylyl-sulfate kinase2.7.1.250.443
1dliUDXUDP-glucose 6-dehydrogenase/0.441
1dljUGAUDP-glucose 6-dehydrogenase/0.441