scPDB - Distribution of Binding site Similarity values of 3ghr entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3ghr	LDT	Aldose reductase	1.1.1.21

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3ghr	LDT	Aldose reductase	1.1.1.21	1.000
3ghs	LDT	Aldose reductase	1.1.1.21	0.874
3ght	LDT	Aldose reductase	1.1.1.21	0.786
2i16	LDT	Aldose reductase	1.1.1.21	0.772
2i17	LDT	Aldose reductase	1.1.1.21	0.755
2fz8	ZST	Aldose reductase	1.1.1.21	0.737
3ld5	LDT	Aldose reductase	1.1.1.21	0.730
3ghu	LDT	Aldose reductase	1.1.1.21	0.723
2pdi	ZST	Aldose reductase	1.1.1.21	0.701
2hvo	ZST	Aldose reductase	1.1.1.21	0.697
2iki	388	Aldose reductase	1.1.1.21	0.687
3g5e	Q74	Aldose reductase	1.1.1.21	0.685
1us0	LDT	Aldose reductase	1.1.1.21	0.673
1z3n	3NA	Aldose reductase	1.1.1.21	0.668
2pdl	TOL	Aldose reductase	1.1.1.21	0.654
2dv0	ZST	Aldose reductase	1.1.1.21	0.650
2dux	ZST	Aldose reductase	1.1.1.21	0.645
2pdm	ZST	Aldose reductase	1.1.1.21	0.639
3m64	393	Aldose reductase	1.1.1.21	0.639
2duz	ZST	Aldose reductase	1.1.1.21	0.638
2hv5	ZST	Aldose reductase	1.1.1.21	0.628
2qxw	LDT	Aldose reductase	1.1.1.21	0.625
2pzn	393	Aldose reductase	1.1.1.21	0.619
2pdp	393	Aldose reductase	1.1.1.21	0.611
3mb9	ZST	Aldose reductase	1.1.1.21	0.611
4gca	2X9	Aldose reductase	1.1.1.21	0.610
1pwl	BFI	Aldose reductase	1.1.1.21	0.606
1z89	62P	Aldose reductase	1.1.1.21	0.600
1iei	ZES	Aldose reductase	1.1.1.21	0.599
1t40	ID5	Aldose reductase	1.1.1.21	0.598
2hvn	ZST	Aldose reductase	1.1.1.21	0.596
2pdb	ZST	Aldose reductase	1.1.1.21	0.595
2pdg	47D	Aldose reductase	1.1.1.21	0.595
3m0i	ZST	Aldose reductase	1.1.1.21	0.590
3mc5	393	Aldose reductase	1.1.1.21	0.590
2pdu	393	Aldose reductase	1.1.1.21	0.589
3lql	LDT	Aldose reductase	1.1.1.21	0.586
2pdh	47D	Aldose reductase	1.1.1.21	0.585
2pdx	ZST	Aldose reductase	1.1.1.21	0.585
2pdn	47D	Aldose reductase	1.1.1.21	0.578
2fz9	ZST	Aldose reductase	1.1.1.21	0.577
3t42	3T4	Aldose reductase	1.1.1.21	0.573
2pdf	ZST	Aldose reductase	1.1.1.21	0.571
2ikh	LIT	Aldose reductase	1.1.1.21	0.568
3m4h	388	Aldose reductase	1.1.1.21	0.568
2pdc	393	Aldose reductase	1.1.1.21	0.565
3lbo	LDT	Aldose reductase	1.1.1.21	0.564
3len	ZST	Aldose reductase	1.1.1.21	0.561
2iqd	LPA	Aldose reductase	1.1.1.21	0.556
2pdq	47D	Aldose reductase	1.1.1.21	0.556
2pdj	393	Aldose reductase	1.1.1.21	0.554
2ikj	393	Aldose reductase	1.1.1.21	0.553
2inz	OHP	Aldose reductase	1.1.1.21	0.553
1t41	ID5	Aldose reductase	1.1.1.21	0.552
2pd5	ZST	Aldose reductase	1.1.1.21	0.551
1frb	ZST	Aldose reductase-related protein 2	/	0.550
2pdy	FID	Aldose reductase	1.1.1.21	0.547
3lz5	LDT	Aldose reductase	1.1.1.21	0.544
2fzd	TOL	Aldose reductase	1.1.1.21	0.541
4yu1	53N	Aldose reductase	1.1.1.21	0.539
1zua	TOL	Aldo-keto reductase family 1 member B10	1.1.1	0.535
2pdw	FID	Aldose reductase	1.1.1.21	0.521
1el3	I84	Aldose reductase	1.1.1.21	0.518
2f2k	TGG	Aldose reductase	1.1.1.21	0.501
1ah3	TOL	Aldose reductase	1.1.1.21	0.499
2aov	C2M	Histamine N-methyltransferase	2.1.1.8	0.492
1p91	SAM	23S rRNA (guanine(745)-N(1))-methyltransferase	/	0.486
3u2c	SUZ	Aldose reductase	1.1.1.21	0.486
3zec	ANP	Adenosine monophosphate-protein transferase SoFic	2.7.7.n1	0.486
1lnm	DTX	Bilin-binding protein	/	0.482
2fzb	TOL	Aldose reductase	1.1.1.21	0.481
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.479
4ga8	SBI	Aldo-keto reductase family 1 member B10	1.1.1	0.477
1eko	I84	Aldose reductase	1.1.1.21	0.474
1yw7	A41	Methionine aminopeptidase 2	/	0.474
5liu	388	Aldo-keto reductase family 1 member B10	1.1.1	0.472
3s3g	TLT	Aldose reductase	1.1.1.21	0.471
2is7	2CL	Aldose reductase	1.1.1.21	0.470
1x8l	OXR	Retinol dehydratase	/	0.469
4c2z	646	Glycylpeptide N-tetradecanoyltransferase 1	/	0.467
4pab	THG	Dimethylglycine dehydrogenase, mitochondrial	1.5.8.4	0.467
2f38	15M	Aldo-keto reductase family 1 member C3	/	0.465
2pdk	SBI	Aldose reductase	1.1.1.21	0.465
4dbs	0HV	Aldo-keto reductase family 1 member C3	/	0.465
1e66	HUX	Acetylcholinesterase	3.1.1.7	0.464
2ea4	F79	Methionine aminopeptidase 2	/	0.464
4bbh	YBN	Glycylpeptide N-tetradecanoyltransferase	/	0.463
3v35	NTI	Aldose reductase	1.1.1.21	0.461
2xup	TZ5	Acetylcholinesterase	3.1.1.7	0.459
1lke	DOG	Bilin-binding protein	/	0.458
1q83	TZ5	Acetylcholinesterase	3.1.1.7	0.458
2iod	MYC	Dihydroflavonol 4-reductase	1.1.1.219	0.458
3f3y	4OA	Bile salt sulfotransferase	2.8.2.14	0.458
4f1l	0RY	Poly [ADP-ribose] polymerase 14	2.4.2.30	0.458
1q23	FUA	Chloramphenicol acetyltransferase	2.3.1.28	0.456
1umc	TDP	2-oxoisovalerate dehydrogenase subunit alpha	1.2.4.4	0.456
1umc	TDP	2-oxoisovalerate dehydrogenase subunit beta	1.2.4.4	0.456
2cbq	TH2	Neocarzinostatin	/	0.456
1ihi	IU5	Aldo-keto reductase family 1 member C2	/	0.454
1odc	A8B	Acetylcholinesterase	3.1.1.7	0.454
2aou	CQA	Histamine N-methyltransferase	2.1.1.8	0.454
2cek	N8T	Acetylcholinesterase	3.1.1.7	0.454
4jq4	IMN	Aldo-keto reductase family 1 member C2	/	0.454
1ah0	SBI	Aldose reductase	1.1.1.21	0.453
2fap	RAD	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.453
2fap	RAD	Serine/threonine-protein kinase mTOR	2.7.11.1	0.453
3p2v	DOY	Aldose reductase	1.1.1.21	0.453
4bfv	ZVV	Pantothenate kinase	2.7.1.33	0.453
2gev	COK	Pantothenate kinase	2.7.1.33	0.452
2aot	2PM	Histamine N-methyltransferase	2.1.1.8	0.451
2xyt	TC9	Soluble acetylcholine receptor	/	0.451
2yne	YNE	Glycylpeptide N-tetradecanoyltransferase	/	0.451
3g58	988	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.451
2agt	FID	Aldose reductase	1.1.1.21	0.450
2wsa	646	Glycylpeptide N-tetradecanoyltransferase	/	0.450
2xnv	VU3	Soluble acetylcholine receptor	/	0.450
2xuj	TZ5	Acetylcholinesterase	3.1.1.7	0.450
1yw9	A84	Methionine aminopeptidase 2	/	0.449
4lsa	BLD	Protein BRASSINOSTEROID INSENSITIVE 1	2.7.10.1	0.449
4u16	3C0	Muscarinic acetylcholine receptor M3	/	0.449
1xor	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.448
3jsx	CC2	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.448
4b11	7I1	Glycylpeptide N-tetradecanoyltransferase	/	0.448
4q0k	GA3	Phytohormone-binding protein	/	0.448
2zsb	ADP	Pantothenate kinase	2.7.1.33	0.447
4mlp	2CX	Cryptochrome-2	/	0.447
1fap	RAP	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.446
1fap	RAP	Serine/threonine-protein kinase mTOR	2.7.11.1	0.446
2nvc	ITA	Aldose reductase	1.1.1.21	0.446
2w6c	BM4	Acetylcholinesterase	3.1.1.7	0.446
3q9b	B3N	Acetylpolyamine amidohydrolase	/	0.446
3r8h	ZOM	Aldo-keto reductase family 1 member C3	/	0.446
3tfu	PL8	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	2.6.1.62	0.446
4li6	1XO	Tankyrase-1	2.4.2.30	0.446
3gf4	UPG	UDP-galactopyranose mutase	5.4.99.9	0.445
2zsd	COA	Pantothenate kinase	2.7.1.33	0.444
3af0	GDP	Pantothenate kinase	2.7.1.33	0.444
3q7f	ED2	Uncharacterized protein	/	0.444
4zzi	1NS	NAD-dependent protein deacetylase sirtuin-1	3.5.1	0.444
1qti	GNT	Acetylcholinesterase	3.1.1.7	0.443
1ry0	PG2	Aldo-keto reductase family 1 member C3	/	0.443
1xf0	ASD	Aldo-keto reductase family 1 member C3	/	0.443
4kp6	1S1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.443
4xwt	U5P	Ribonuclease J	/	0.443
2get	COK	Pantothenate kinase	2.7.1.33	0.442
4dbu	BT9	Aldo-keto reductase family 1 member C3	/	0.442
4jt8	1NR	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	3.5.1	0.442
1al7	HST	Peroxisomal (S)-2-hydroxy-acid oxidase	1.1.3.15	0.441
1o1s	1NH	Protein farnesyltransferase subunit beta	2.5.1.58	0.441
3n3z	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.441
4lcn	GNG	Cytidine and deoxycytidylate deaminase zinc-binding region	/	0.441
4li8	1XQ	Tankyrase-1	2.4.2.30	0.441
1aqu	EST	Estrogen sulfotransferase, testis isoform	2.8.2.4	0.440
1oyn	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.440
3af2	ACP	Pantothenate kinase	2.7.1.33	0.440
3dyl	PCG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.440
3fap	ARD	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.440
3fap	ARD	Serine/threonine-protein kinase mTOR	2.7.11.1	0.440
3v94	WYQ	Phosphodiesterase	/	0.440
4b13	X25	Glycylpeptide N-tetradecanoyltransferase	/	0.440
4g2l	0WL	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.440
4hhz	15S	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.440