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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.11.000
3mv5XFERAC-alpha serine/threonine-protein kinase2.7.11.10.560
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.527
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.519
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.514
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
5auxKMPDeath-associated protein kinase 12.7.11.10.503
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.501
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
4otiMI1Serine/threonine-protein kinase N1/0.499
4bbfO19Tyrosine-protein kinase JAK2/0.498
3mvjXFEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
4l445FIRibosomal protein S6 kinase beta-12.7.11.10.491
1fvv107Cyclin-dependent kinase 22.7.11.220.488
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
3nynSGVG protein-coupled receptor kinase 62.7.11.160.484
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.483
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
2ckeIQUDeath-associated protein kinase 2/0.482
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.481
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2ijmADPFocal adhesion kinase 12.7.10.20.479
4c35NU3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.479
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.479
5auvAGIDeath-associated protein kinase 12.7.11.10.479
3gu6ADPDeath-associated protein kinase 12.7.11.10.477
4bbe3O4Tyrosine-protein kinase JAK2/0.477
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.475
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.475
1jklANPDeath-associated protein kinase 12.7.11.10.469
1wvxBD4Death-associated protein kinase 12.7.11.10.469
5av4GENDeath-associated protein kinase 12.7.11.10.469
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.467
3gubGUBDeath-associated protein kinase 12.7.11.10.467
3zh8C58Protein kinase C iota type2.7.11.130.467
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.466
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.464
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.463
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.462
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.462
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2etkHFSRho-associated protein kinase 12.7.11.10.460
3bhy7CPDeath-associated protein kinase 3/0.459
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.458
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.458
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.458
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.457
5auzGENDeath-associated protein kinase 12.7.11.10.457
4lv7ADPInositol-pentakisphosphate 2-kinase2.7.1.1580.456
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4aqkADPInositol-pentakisphosphate 2-kinase2.7.1.1580.455
5auwQUEDeath-associated protein kinase 12.7.11.10.455
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.454
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.454
3nux3NVCyclin-dependent kinase 62.7.11.220.454
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.453
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2xanANPInositol-pentakisphosphate 2-kinase2.7.1.1580.453
3lpbNVBTyrosine-protein kinase JAK2/0.453
3ncz3NCRho-associated protein kinase 12.7.11.10.453
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.452
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3qfvNM7Serine/threonine-protein kinase MRCK beta2.7.11.10.451
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.451
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.451
4hvi19STyrosine-protein kinase JAK32.7.10.20.451
5av2KMPDeath-associated protein kinase 12.7.11.10.450
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.449
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.449
3w2sW2REpidermal growth factor receptor2.7.10.10.449
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.449
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.449
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.448
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.447
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.447
3ezvEZVCyclin-dependent kinase 22.7.11.220.447
3v8s0HDRho-associated protein kinase 12.7.11.10.447
5av3KMPDeath-associated protein kinase 12.7.11.10.447
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.446
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.446
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.445
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.445
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.445
3ezrEZRCyclin-dependent kinase 22.7.11.220.445
3pe2E1BCasein kinase II subunit alpha2.7.11.10.445
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3a62STURibosomal protein S6 kinase beta-12.7.11.10.444
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.444
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.444
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.443
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.443
4j97ACPFibroblast growth factor receptor 2/0.443
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3juhANPCasein kinase II subunit alpha2.7.11.10.442
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4eol1ROCyclin-dependent kinase 22.7.11.220.442
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.442
1yvj4STTyrosine-protein kinase JAK32.7.10.20.441
2etrY27Rho-associated protein kinase 12.7.11.10.441
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.441
4jrnANPRhoptry kinase family protein/0.441
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.441
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.440
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.440
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.440
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.440