sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.726 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.712 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.708 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.706 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.699 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.695 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.695 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.691 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.686 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.681 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.680 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.677 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.675 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.672 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.670 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.668 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.668 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.661 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.658 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.656 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.654 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.643 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.634 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.634 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.608 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.602 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.554 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.539 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.523 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.516 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.515 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.513 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.513 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.510 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.510 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.508 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.498 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.491 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.484 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.484 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.482 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.478 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.477 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.474 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.474 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.471 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.470 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.468 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.463 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.463 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.463 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 2y3r | TRK | TamL | / | 0.460 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.458 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.458 | |
| 2c6h | PXI | Cytochrome P450 monooxygenase PikC | / | 0.457 | |
| 3zuy | TCH | Transporter | / | 0.456 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.456 | |
| 3u9e | COA | Lmo1369 protein | / | 0.455 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.454 | |
| 1aj8 | COA | Citrate synthase | / | 0.453 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.452 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.451 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.451 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.451 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.451 | |
| 2y4g | TIR | TamL | / | 0.450 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.449 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.448 | |
| 3gob | HXX | DdmC | / | 0.448 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.448 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.448 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.447 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.446 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.446 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.446 | |
| 4xj4 | 3AT | Cyclic GMP-AMP synthase | / | 0.446 | |
| 5a3c | NAD | SIR2 family protein | / | 0.446 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.445 | |
| 1ee9 | NAD | Methylenetetrahydrofolate dehydrogenase [NAD(+)] | 1.5.1.15 | 0.444 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.444 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.441 | |
| 2ya3 | J7V | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.441 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.441 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.441 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.441 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.440 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 |